Azetidines/therapeutic use; Betacoronavirus/pathogenicity; Coronavirus Infections/drug therapy; Interferon-alpha/therapeutic use; Interferon-beta/therapeutic use; Interferons/therapeutic use; Pneumonia, Viral/drug therapy; Sulfonamides/therapeutic use; Betacoronavirus/immunology; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/pathology; Coronavirus Infections/virology; Gene Expression Regulation; Humans; Immunity, Cellular/drug effects; Immunity, Humoral/drug effects; Interferon Regulatory Factors/genetics; Interferon Regulatory Factors/immunology; Interferon-alpha/genetics; Interferon-alpha/immunology; Interferon-beta/genetics; Interferon-beta/immunology; Interferons/genetics; Interferons/immunology; Interleukin-1/genetics; Interleukin-1/immunology; Interleukin-6/antagonists & inhibitors; Interleukin-6/genetics; Interleukin-6/immunology; Janus Kinase 1/antagonists & inhibitors; Janus Kinase 1/genetics; Janus Kinase 1/immunology; Lung/drug effects; Lung/immunology; Lung/pathology; Pandemics; Pneumonia, Viral/immunology; Pneumonia, Viral/pathology; Pneumonia, Viral/virology; Purines; Pyrazoles; SARS-CoV-2; Severity of Illness Index; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/immunology