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Updates on community acquired pneumonia management in the ICU.
Nair, Girish B; Niederman, Michael S.
  • Nair GB; Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA. Electronic address: girish.nair@beaumont.org.
  • Niederman MS; Weill Cornell Medical College, Pulmonary and Critical Care, New York Presbyterian/ Weill Cornell Medical Center, New York, NY, USA. Electronic address: msn9004@med.cornell.edu.
Pharmacol Ther ; 217: 107663, 2021 01.
Article in English | MEDLINE | ID: covidwho-713921
ABSTRACT
While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecular testing have improved the identification of co-existent pathogens. However, mortality in patients admitted to ICU remains staggeringly high. The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. The common theme is use of timely, appropriate and adequate antibiotic coverage to decrease mortality and avoid drug resistance. Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Community-Acquired Infections / Disease Management / Intensive Care Units Type of study: Prognostic study Limits: Humans Language: English Journal: Pharmacol Ther Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Community-Acquired Infections / Disease Management / Intensive Care Units Type of study: Prognostic study Limits: Humans Language: English Journal: Pharmacol Ther Year: 2021 Document Type: Article