Your browser doesn't support javascript.
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.
Ntaios, George; Michel, Patrik; Georgiopoulos, Georgios; Guo, Yutao; Li, Wencheng; Xiong, Jing; Calleja, Patricia; Ostos, Fernando; González-Ortega, Guillermo; Fuentes, Blanca; Alonso de Leciñana, María; Díez-Tejedor, Exuperio; García-Madrona, Sebastian; Masjuan, Jaime; DeFelipe, Alicia; Turc, Guillaume; Gonçalves, Bruno; Domigo, Valerie; Dan, Gheorghe-Andrei; Vezeteu, Roxana; Christensen, Hanne; Christensen, Louisa Marguerite; Meden, Per; Hajdarevic, Lejla; Rodriguez-Lopez, Angela; Díaz-Otero, Fernando; García-Pastor, Andrés; Gil-Nuñez, Antonio; Maslias, Errikos; Strambo, Davide; Werring, David J; Chandratheva, Arvind; Benjamin, Laura; Simister, Robert; Perry, Richard; Beyrouti, Rahma; Jabbour, Pascal; Sweid, Ahmad; Tjoumakaris, Stavropoula; Cuadrado-Godia, Elisa; Campello, Ana Rodríguez; Roquer, Jaume; Moreira, Tiago; Mazya, Michael V; Bandini, Fabio; Matz, Karl; Iversen, Helle K; González-Duarte, Alejandra; Tiu, Cristina; Ferrari, Julia.
  • Ntaios G; Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N.).
  • Michel P; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital, Switzerland (P.M., E.M., D. Strambo).
  • Georgiopoulos G; School of Biomedical Engineering and Imaging Sciences, King's College, London, United Kingdom (G.G.).
  • Guo Y; Department of Cardiology, Chinese PLA General Hospital, Beijing, China (Y.G.).
  • Li W; Department of Urology (W.L.), Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, China.
  • Xiong J; Department of Nephrology (J.X.), Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, China.
  • Calleja P; Department of Neurology and Stroke Center, Doce de Octubre University Hospital, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain (P.C., F.O., G.G.-O.).
  • Ostos F; Department of Neurology and Stroke Center, Doce de Octubre University Hospital, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain (P.C., F.O., G.G.-O.).
  • González-Ortega G; Department of Neurology and Stroke Center, Doce de Octubre University Hospital, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain (P.C., F.O., G.G.-O.).
  • Fuentes B; Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Madrid, Spain (B.F., M.A.d.L., E.D.-T.).
  • Alonso de Leciñana M; Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Madrid, Spain (B.F., M.A.d.L., E.D.-T.).
  • Díez-Tejedor E; Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Madrid, Spain (B.F., M.A.d.L., E.D.-T.).
  • García-Madrona S; Department of Neurology and Stroke Centre, Ramón y Cajal University Hospital, IRYCIS Health Research Institute, Madrid, Spain (S.G.-M., J.M., A.D.).
  • Masjuan J; Department of Neurology and Stroke Centre, Ramón y Cajal University Hospital, IRYCIS Health Research Institute, Madrid, Spain (S.G.-M., J.M., A.D.).
  • DeFelipe A; Department of Neurology and Stroke Centre, Ramón y Cajal University Hospital, IRYCIS Health Research Institute, Madrid, Spain (S.G.-M., J.M., A.D.).
  • Turc G; Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Université de Paris, INSERM U1266, and FHU Neurovasc, France (G.T., B.G., V.D.).
  • Gonçalves B; Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Université de Paris, INSERM U1266, and FHU Neurovasc, France (G.T., B.G., V.D.).
  • Domigo V; Intensive Care Unit, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil (B.G.).
  • Dan GA; Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Université de Paris, INSERM U1266, and FHU Neurovasc, France (G.T., B.G., V.D.).
  • Vezeteu R; Colentina University Hospital, Medicine Faculty, University of Medicine "Carol Davila"-Bucharest, Romania (G.-A.D., R.V.).
  • Christensen H; Colentina University Hospital, Medicine Faculty, University of Medicine "Carol Davila"-Bucharest, Romania (G.-A.D., R.V.).
  • Christensen LM; Bispebjerg Hospital & University of Copenhagen, Denmark (H.C., L.M.C., P.M., L.H.).
  • Meden P; Bispebjerg Hospital & University of Copenhagen, Denmark (H.C., L.M.C., P.M., L.H.).
  • Hajdarevic L; Bispebjerg Hospital & University of Copenhagen, Denmark (H.C., L.M.C., P.M., L.H.).
  • Rodriguez-Lopez A; Bispebjerg Hospital & University of Copenhagen, Denmark (H.C., L.M.C., P.M., L.H.).
  • Díaz-Otero F; Vascular Neurology Section - Stroke Center, Hospital General Universitario Gregorio Marañón, Madrid, Spain (A.R.L., F.D.O., A.G.P., A.G.-N.).
  • García-Pastor A; Vascular Neurology Section - Stroke Center, Hospital General Universitario Gregorio Marañón, Madrid, Spain (A.R.L., F.D.O., A.G.P., A.G.-N.).
  • Gil-Nuñez A; Vascular Neurology Section - Stroke Center, Hospital General Universitario Gregorio Marañón, Madrid, Spain (A.R.L., F.D.O., A.G.P., A.G.-N.).
  • Maslias E; Vascular Neurology Section - Stroke Center, Hospital General Universitario Gregorio Marañón, Madrid, Spain (A.R.L., F.D.O., A.G.P., A.G.-N.).
  • Strambo D; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital, Switzerland (P.M., E.M., D. Strambo).
  • Werring DJ; Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital, Switzerland (P.M., E.M., D. Strambo).
  • Chandratheva A; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Benjamin L; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Simister R; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Perry R; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Beyrouti R; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Jabbour P; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom (D.J.W., A.C., L.B., R.S., R.P., R.B.).
  • Sweid A; Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA (P.J., A.S., S.T.).
  • Tjoumakaris S; Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA (P.J., A.S., S.T.).
  • Cuadrado-Godia E; Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA (P.J., A.S., S.T.).
  • Campello AR; Stroke Unit, Department of Neurology, Hospital del Mar (E.C.-G., A.R.C., J.R.).
  • Roquer J; Neurovascular Research Group, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, Spain (E.C.-G., A.R.C., J.R.).
  • Moreira T; Stroke Unit, Department of Neurology, Hospital del Mar (E.C.-G., A.R.C., J.R.).
  • Mazya MV; Neurovascular Research Group, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, Spain (E.C.-G., A.R.C., J.R.).
  • Bandini F; Stroke Unit, Department of Neurology, Hospital del Mar (E.C.-G., A.R.C., J.R.).
  • Matz K; Neurovascular Research Group, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, Spain (E.C.-G., A.R.C., J.R.).
  • Iversen HK; Department of Clinical Neuroscience (T.M., M.V.M.), Karolinska Institutet, Stockholm, Sweden.
  • González-Duarte A; Department of Neurology (T.M., M.V.M.), Karolinska Institutet, Stockholm, Sweden.
  • Tiu C; Department of Clinical Neuroscience (T.M., M.V.M.), Karolinska Institutet, Stockholm, Sweden.
  • Ferrari J; Department of Neurology (T.M., M.V.M.), Karolinska Institutet, Stockholm, Sweden.
Stroke ; 51(9): e254-e258, 2020 09.
Article in English | MEDLINE | ID: covidwho-992145
ABSTRACT
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 11 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 11 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Brain Ischemia / Coronavirus Infections / Stroke Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Stroke Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Brain Ischemia / Coronavirus Infections / Stroke Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Stroke Year: 2020 Document Type: Article