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Diagnosis of COVID-19 using multiple antibody assays in two cases with negative PCR results from nasopharyngeal swabs.
Traugott, Marianna Theresia; Hoepler, Wolfgang; Seitz, Tamara; Baumgartner, Sebastian; Karolyi, Mario; Pawelka, Erich; Friese, Emanuela; Neuhold, Stephanie; Kelani, Hasan; Thalhammer, Florian; Zoufaly, Alexander; Laferl, Hermann; Aberle, Judith Helene; Wenisch, Christoph; Puchhammer-Stöckl, Elisabeth; Stiasny, Karin; Aberle, Stephan Walter; Weseslindtner, Lukas.
  • Traugott MT; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Hoepler W; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Seitz T; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Baumgartner S; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Karolyi M; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Pawelka E; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Friese E; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Neuhold S; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Kelani H; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Thalhammer F; Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University Vienna, Vienna, Austria.
  • Zoufaly A; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Laferl H; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Aberle JH; Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
  • Wenisch C; 4th Medical Department, Department of Infectious Diseases and Tropical Medicine, Kaiser-Franz-Josef Hospital, Vienna, Austria.
  • Puchhammer-Stöckl E; Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
  • Stiasny K; Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
  • Aberle SW; Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
  • Weseslindtner L; Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria. lukas.weseslindtner@meduniwien.ac.at.
Infection ; 49(1): 171-175, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-714361
ABSTRACT
We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enzyme-Linked Immunosorbent Assay / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-020-01497-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enzyme-Linked Immunosorbent Assay / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-020-01497-2