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Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.
Udrea, Ana-Maria; Avram, Speranta; Nistorescu, Simona; Pascu, Mihail-Lucian; Romanitan, Mihaela Oana.
  • Udrea AM; Laser Department, National Institute for Laser, Plasma and Radiation Physics, Magurele, Ilfov, Romania; Department of Anatomy, Animal Biology, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.
  • Avram S; Department of Anatomy, Animal Biology, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.
  • Nistorescu S; Laser Department, National Institute for Laser, Plasma and Radiation Physics, Magurele, Ilfov, Romania; Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania.
  • Pascu ML; Laser Department, National Institute for Laser, Plasma and Radiation Physics, Magurele, Ilfov, Romania; Faculty of Physics, University of Bucharest, Magurele, Romania. Electronic address: mihai.pascu@inflpr.ro.
  • Romanitan MO; Stockholm South General Hospital, Department of Emergency internal medicine and Neurology, Karolinska Institute Stroke Research Network at Södersjukhuset, 118 83 Stockholm, Sweden.
J Photochem Photobiol B ; 211: 111997, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-714374
ABSTRACT
The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (Mpro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with NdYAG laser beam at 266 nm respectively 355 nm. Our results reveal that thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus Mpro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak. Such results recommend these medicines for further tests on cell cultures infected with SARS-CoV-2 or animal model. The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phenothiazines / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Photochem Photobiol B Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: J.jphotobiol.2020.111997

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phenothiazines / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Photochem Photobiol B Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: J.jphotobiol.2020.111997