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[Correlation between hyponatremia and the severity of coronavirus disease 2019].
Zhang, Weidai; Lu, Senrong; Zhang, Mianfeng; Zheng, Hongbin; Huang, Yuhan; Chen, Suzhi; Kang, Huizhong; Wu, Suwu.
  • Zhang W; Department of Cardiology, Cardiology Intensive Care Unit, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Lu S; Department of Emergency Intensive Care Unit, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Zhang M; Department of Intensive Care Unit, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Zheng H; Department of Respiratory, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Huang Y; Department of Endocrinology, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Chen S; Department of Intensive Care Unit, Shantou Central Hospital, Shantou 515000, Guangdong, China.
  • Kang H; Department of Infectious Disease, Shantou Central Hospital, Shantou 515000, Guangdong, China. Corresponding author: Wu Suwu, Email: wsw0754@163.com.
  • Wu S; Department of Intensive Care Unit, Shantou Central Hospital, Shantou 515000, Guangdong, China.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(7): 774-778, 2020 Jul.
Article in Chinese | MEDLINE | ID: covidwho-714510
ABSTRACT

OBJECTIVE:

To investigate the correlation between hyponatremia and the severity of coronavirus disease 2019 (COVID-19).

METHODS:

Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Na+ level in the patients with COVID-19.

RESULTS:

Among the 12 patients with COVID-19, there were 8 males and 4 females with the mean age of (38.0±16.3) years old, most of them were admitted to the hospital with cough and/or fever. All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. All patients were of ordinary type when they were admitted to the hospital. Among them, 1 patient turned into a severe case during the course of the disease, and 1 patient showed a tendency to become severe case. It was found that 10 patients without severe conversion had an average blood Na+ of (138.3±1.3) mmol/L at admission, and the lowest blood Na+ during the course of disease was (135.9±3.1) mmol/L. However, 2 patients who became severe and had a tendency to become severe disease (Na+ levels at admission were 140.0 mmol/L and 138.0 mmol/L, respectively) experienced hyponatremia during the course of the disease (the lowest blood Na+ levels were 129.0 mmol/L and 122.0 mmol/L). Further analysis showed that the lower serum Na+ level, the higher level of white blood cell count (WBC) and C-reactive protein (CRP), but serum Na+ level was consistent with the change trend of lymphocytes, suggesting that hyponatremia was closely correlated with severe inflammation reaction.

CONCLUSIONS:

Serum Na+ showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. It was necessary to pay great attention to the change trend of blood Na+ level. However, further research was needed to obtain more reliable conclusions and explorer the pathophysiological mechanisms.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Hyponatremia Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article Affiliation country: Cma.j.cn121430-20200331-00417

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Hyponatremia Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article Affiliation country: Cma.j.cn121430-20200331-00417