Your browser doesn't support javascript.
Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID-19.
Pierzynowska, Karolina; Gaffke, Lidia; Wegrzyn, Grzegorz.
  • Pierzynowska K; Department of Molecular Biology, University of Gdansk, Gdansk, Poland.
  • Gaffke L; Department of Molecular Biology, University of Gdansk, Gdansk, Poland.
  • Wegrzyn G; Department of Molecular Biology, University of Gdansk, Gdansk, Poland.
FEBS Lett ; 594(20): 3363-3370, 2020 10.
Article in English | MEDLINE | ID: covidwho-716193
ABSTRACT
We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that MPS cells might be less, rather than more, susceptible to SARS-CoV-2 infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Mucopolysaccharidoses / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: FEBS Lett Year: 2020 Document Type: Article Affiliation country: 1873-3468.13908

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Mucopolysaccharidoses / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: FEBS Lett Year: 2020 Document Type: Article Affiliation country: 1873-3468.13908