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SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface.
Chen, Wei; Yuan, Peng; Yang, Ming; Yan, Zhiqiang; Kong, Siming; Yan, Jie; Liu, Xixi; Chen, Yidong; Qiao, Jie; Yan, Liying.
  • Chen W; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
  • Yuan P; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China.
  • Yang M; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China.
  • Yan Z; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
  • Kong S; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
  • Yan J; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
  • Liu X; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China.
  • Chen Y; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China.
  • Qiao J; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
  • Yan L; Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China.
Engineering (Beijing) ; 6(10): 1162-1169, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-716696
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world, leading to large-scale population infection. Angiotensin-converting enzyme 2 (ACE2) is the receptor of both severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. However, it is still controversial whether vertical transmission exists. In order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2 and TMPRSS2 (encoding transmembrane protease serine 2) expression patterns in peri-implantation embryos and the maternal-fetal interface using previously published single-cell transcriptome data. The results showed that day 6 (D6) trophectoderm (TE) cells in peri-implantation embryos, as well as syncytiotrophoblast (STB) at 8 weeks of gestation (STB_8W) and extravillous trophoblast (EVT) cells at 24 weeks of gestation (EVT_24W) in the maternal-fetal interface, strongly co-expressed ACE2 and TMPRSS2, indicating a SARS-CoV-2 infection susceptibility. The ACE2 positive-expressing cells in the three cell types mentioned above were found to share common characteristics, which were involved in autophagy and immune-related processes. ACE2 showed no gender bias in post-implantation embryos but showed a significant gender difference in D6_TE, D6 primitive endoderm (PE) cells, and ACE2 positive-expressing STBs. These findings suggest that there may be different SARS-CoV-2 infection susceptibilities of D6 embryos of different genders and during the gestation of different genders. Our results reveal potential SARS-CoV-2 infection risks during embryo transfer, peri-implantation embryo development, and gestation.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Engineering (Beijing) Year: 2020 Document Type: Article Affiliation country: J.eng.2020.07.013

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Engineering (Beijing) Year: 2020 Document Type: Article Affiliation country: J.eng.2020.07.013