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Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety.
O'Hearn, K; Gertsman, S; Sampson, M; Webster, R; Tsampalieros, A; Ng, R; Gibson, J; Lobos, A T; Acharya, N; Agarwal, A; Boggs, S; Chamberlain, G; Staykov, E; Sikora, L; McNally, J D.
  • O'Hearn K; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
  • Gertsman S; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
  • Sampson M; Library Services, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Webster R; Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Tsampalieros A; Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Ng R; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
  • Gibson J; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
  • Lobos AT; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Acharya N; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
  • Agarwal A; Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
  • Boggs S; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Chamberlain G; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Staykov E; Department of Biology, University of Ottawa, Ottawa, ON, Canada.
  • Sikora L; Health Sciences Library, University of Ottawa, Ottawa, ON, Canada.
  • McNally JD; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. Electronic address: dmcnally@cheo.on.ca.
J Hosp Infect ; 106(1): 163-175, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-716812
Semantic information from SemMedBD (by NLM)
1. Mechanical Ventilator TREATS Health Personnel
Subject
Mechanical Ventilator
Predicate
TREATS
Object
Health Personnel
2. Decontamination USES Mechanical Ventilator
Subject
Decontamination
Predicate
USES
Object
Mechanical Ventilator
3. Mechanical Ventilator TREATS Health Personnel
Subject
Mechanical Ventilator
Predicate
TREATS
Object
Health Personnel
4. Decontamination USES Mechanical Ventilator
Subject
Decontamination
Predicate
USES
Object
Mechanical Ventilator
ABSTRACT
Inadequate supply of filtering facepiece respirators (FFRs) for healthcare workers during a pandemic such as the novel coronavirus outbreak (SARS-CoV-2) is a serious public health issue. The aim of this study was to synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) for N95 FFR decontamination. A systematic review (PROSPERO CRD42020176156) was conducted on UVGI in N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined eligibility and extracted predefined variables. Original research reporting on function, decontamination, or mask fit following UVGI were included. Thirteen studies were identified, comprising 54 UVGI intervention arms and 58 N95 models. FFRs consistently maintained certification standards following UVGI. Aerosol penetration averaged 1.19% (0.70-2.48%) and 1.14% (0.57-2.63%) for control and UVGI arms, respectively. Airflow resistance for the control arms averaged 9.79 mm H2O (7.97-11.70 mm H2O) vs 9.85 mm H2O (8.33-11.44 mm H2O) for UVGI arms. UVGI protocols employing a cumulative dose >20,000 J/m2 resulted in a 2-log reduction in viral load. A >3-log reduction was observed in seven UVGI arms using >40,000 J/m2. Impact of UVGI on fit was evaluated in two studies (16,200; 32,400 J/m2) and no evidence of compromise was found. Our findings suggest that further work in this area (or translation to a clinical setting) should use a cumulative UV-C dose of 40,000 J/m2 or greater, and confirm appropriate mask fit following decontamination.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Ultraviolet Rays / Disinfection / Occupational Exposure / Guidelines as Topic / Equipment Reuse / Coronavirus Infections / Pandemics / Masks Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article Affiliation country: J.jhin.2020.07.014

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Ultraviolet Rays / Disinfection / Occupational Exposure / Guidelines as Topic / Equipment Reuse / Coronavirus Infections / Pandemics / Masks Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article Affiliation country: J.jhin.2020.07.014