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Could aquaporin modulators be employed as prospective drugs for COVID-19 related pulmonary comorbidity?
Mariajoseph-Antony, Lezy Flora; Kannan, Arun; Panneerselvam, Antojenifer; Loganathan, Chithra; Anbarasu, Kumarasamy; Prahalathan, Chidambaram.
  • Mariajoseph-Antony LF; Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.
  • Kannan A; Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.
  • Panneerselvam A; Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.
  • Loganathan C; Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.
  • Anbarasu K; Microbial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, India.
  • Prahalathan C; Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India. Electronic address: prahalath@gmail.com.
Med Hypotheses ; 143: 110201, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-716876
ABSTRACT
COVID-19 initially an epidemic caused by SARS-CoV-2 has turned out to be a life- threatening global pandemic with increased morbidity and mortality. The presence of cytokine storm has been linked with the pathogenesis of severe lung injury as evinced in COVID-19. Aquaporins (AQPs) are molecular water channels, facilitating water transport across the cell membrane in response to osmotic gradients. Impairment in alveolar fluid clearance due to altered functional expression of respiratory AQPs highlight their pathophysiological significance in pulmonary edema associated respiratory illness. Therefore, we hypothesize that targeted modulation of AQPs in lungs in the intervening period of time, could diminish the dreadful effects of inflammation- induced comorbidity in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Edema / Coronavirus Infections / Aquaporins Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.110201

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Edema / Coronavirus Infections / Aquaporins Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.110201