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Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals.
Zhang, Fan; Gan, Rui; Zhen, Ziqi; Hu, Xiaoli; Li, Xiang; Zhou, Fengxia; Liu, Ying; Chen, Chuangeng; Xie, Shuangyu; Zhang, Bailing; Wu, Xiaoke; Huang, Zhiwei.
  • Zhang F; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Gan R; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Zhen Z; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Hu X; Department of Infectious Diseases, Heilongjiang Provincial Hospital, Harbin Institute of Technology, Harbin, 150030, China.
  • Li X; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Zhou F; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Liu Y; Harbin Blood Center, Harbin, 150056, China.
  • Chen C; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Xie S; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Zhang B; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Wu X; Centre for Reproductive Medicine, Heilongjiang Provincial Hospital, Harbin Institute of Technology, Harbin, 150030, China.
  • Huang Z; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Signal Transduct Target Ther ; 5(1): 156, 2020 08 14.
Article in English | MEDLINE | ID: covidwho-717099
ABSTRACT
The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has affected more than eight million people. There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients. In this study, we profiled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-cell RNA and TCR/BCR V(D)J sequencing. The sequencing data revealed SARS-CoV-2-specific shuffling of adaptive immune repertories and COVID-19-induced remodeling of peripheral lymphocytes. Characterization of variations in the peripheral T and B cells from the COVID-19 patients revealed a positive correlation of humoral immune response and T-cell immune memory with disease severity. Sequencing and functional data revealed SARS-CoV-2-specific T-cell immune memory in the convalescent COVID-19 patients. Furthermore, we also identified novel antigens that are responsive in the convalescent patients. Altogether, our study reveals adaptive immune repertories underlying pathogenesis and recovery in severe versus mild COVID-19 patients, providing valuable information for potential vaccine and therapeutic development against SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / T-Lymphocytes / Coronavirus Infections / Immunity, Humoral / Betacoronavirus / Immunity, Cellular Type of study: Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Asia Language: English Journal: Signal Transduct Target Ther Year: 2020 Document Type: Article Affiliation country: S41392-020-00263-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / T-Lymphocytes / Coronavirus Infections / Immunity, Humoral / Betacoronavirus / Immunity, Cellular Type of study: Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Asia Language: English Journal: Signal Transduct Target Ther Year: 2020 Document Type: Article Affiliation country: S41392-020-00263-y