Your browser doesn't support javascript.
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.
Wu, Shipo; Zhong, Gongxun; Zhang, Jun; Shuai, Lei; Zhang, Zhe; Wen, Zhiyuan; Wang, Busen; Zhao, Zhenghao; Song, Xiaohong; Chen, Yi; Liu, Renqiang; Fu, Ling; Zhang, Jinlong; Guo, Qiang; Wang, Chong; Yang, Yilong; Fang, Ting; Lv, Peng; Wang, Jinliang; Xu, Junjie; Li, Jianmin; Yu, Changming; Hou, Lihua; Bu, Zhigao; Chen, Wei.
  • Wu S; Beijing Institute of Biotechnology, Beijing, China.
  • Zhong G; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Zhang J; Beijing Institute of Biotechnology, Beijing, China.
  • Shuai L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Zhang Z; Beijing Institute of Biotechnology, Beijing, China.
  • Wen Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Wang B; Beijing Institute of Biotechnology, Beijing, China.
  • Zhao Z; Beijing Institute of Biotechnology, Beijing, China.
  • Song X; Beijing Institute of Biotechnology, Beijing, China.
  • Chen Y; Beijing Institute of Biotechnology, Beijing, China.
  • Liu R; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Fu L; Beijing Institute of Biotechnology, Beijing, China.
  • Zhang J; Beijing Institute of Biotechnology, Beijing, China.
  • Guo Q; Beijing Institute of Biotechnology, Beijing, China.
  • Wang C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Yang Y; Beijing Institute of Biotechnology, Beijing, China.
  • Fang T; Beijing Institute of Biotechnology, Beijing, China.
  • Lv P; Beijing Institute of Biotechnology, Beijing, China.
  • Wang J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Xu J; Beijing Institute of Biotechnology, Beijing, China.
  • Li J; Beijing Institute of Biotechnology, Beijing, China.
  • Yu C; Beijing Institute of Biotechnology, Beijing, China.
  • Hou L; Beijing Institute of Biotechnology, Beijing, China. houlihua@sina.com.
  • Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China. buzhigao@caas.cn.
  • Chen W; Beijing Institute of Biotechnology, Beijing, China. cw0226@foxmail.com.
Nat Commun ; 11(1): 4081, 2020 08 14.
Article in English | MEDLINE | ID: covidwho-717117
Semantic information from SemMedBD (by NLM)
1. Adenovirus Vaccine PART_OF Disease Vectors
Subject
Adenovirus Vaccine
Predicate
PART_OF
Object
Disease Vectors
2. Vaccines TREATS Communicable Diseases
Subject
Vaccines
Predicate
TREATS
Object
Communicable Diseases
3. M Protei PART_OF C5203676
Subject
M Protei
Predicate
PART_OF
Object
C5203676
4. Mucous Membrane LOCATION_OF Vaccination
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
Vaccination
5. Adenovirus Vaccine PART_OF Disease Vectors
Subject
Adenovirus Vaccine
Predicate
PART_OF
Object
Disease Vectors
6. Vaccines TREATS Communicable Diseases
Subject
Vaccines
Predicate
TREATS
Object
Communicable Diseases
7. M Protein, multiple myeloma PART_OF 2019 novel coronavirus
Subject
M Protein, multiple myeloma
Predicate
PART_OF
Object
2019 novel coronavirus
8. Mucous Membrane LOCATION_OF Vaccination
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
Vaccination
ABSTRACT
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17972-1

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17972-1