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A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.
Wu, Shipo; Zhong, Gongxun; Zhang, Jun; Shuai, Lei; Zhang, Zhe; Wen, Zhiyuan; Wang, Busen; Zhao, Zhenghao; Song, Xiaohong; Chen, Yi; Liu, Renqiang; Fu, Ling; Zhang, Jinlong; Guo, Qiang; Wang, Chong; Yang, Yilong; Fang, Ting; Lv, Peng; Wang, Jinliang; Xu, Junjie; Li, Jianmin; Yu, Changming; Hou, Lihua; Bu, Zhigao; Chen, Wei.
  • Wu S; Beijing Institute of Biotechnology, Beijing, China.
  • Zhong G; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Zhang J; Beijing Institute of Biotechnology, Beijing, China.
  • Shuai L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Zhang Z; Beijing Institute of Biotechnology, Beijing, China.
  • Wen Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Wang B; Beijing Institute of Biotechnology, Beijing, China.
  • Zhao Z; Beijing Institute of Biotechnology, Beijing, China.
  • Song X; Beijing Institute of Biotechnology, Beijing, China.
  • Chen Y; Beijing Institute of Biotechnology, Beijing, China.
  • Liu R; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Fu L; Beijing Institute of Biotechnology, Beijing, China.
  • Zhang J; Beijing Institute of Biotechnology, Beijing, China.
  • Guo Q; Beijing Institute of Biotechnology, Beijing, China.
  • Wang C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Yang Y; Beijing Institute of Biotechnology, Beijing, China.
  • Fang T; Beijing Institute of Biotechnology, Beijing, China.
  • Lv P; Beijing Institute of Biotechnology, Beijing, China.
  • Wang J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Xu J; Beijing Institute of Biotechnology, Beijing, China.
  • Li J; Beijing Institute of Biotechnology, Beijing, China.
  • Yu C; Beijing Institute of Biotechnology, Beijing, China.
  • Hou L; Beijing Institute of Biotechnology, Beijing, China. houlihua@sina.com.
  • Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China. buzhigao@caas.cn.
  • Chen W; Beijing Institute of Biotechnology, Beijing, China. cw0226@foxmail.com.
Nat Commun ; 11(1): 4081, 2020 08 14.
Article in English | MEDLINE | ID: covidwho-717117
ABSTRACT
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Prognostic study Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17972-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Prognostic study Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17972-1