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Epilepsy in time of COVID-19: A survey-based study.
Fonseca, Elena; Quintana, Manuel; Lallana, Sofía; Luis Restrepo, Juan; Abraira, Laura; Santamarina, Estevo; Seijo-Raposo, Iván; Toledo, Manuel.
  • Fonseca E; Epilepsy Unit Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Quintana M; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Lallana S; Epilepsy Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
  • Luis Restrepo J; Epilepsy Unit Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Abraira L; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Santamarina E; Epilepsy Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
  • Seijo-Raposo I; Epilepsy Unit Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Toledo M; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
Acta Neurol Scand ; 142(6): 545-554, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-717275
Semantic information from SemMedBD (by NLM)
1. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
2. Patients LOCATION_OF IMPACT gene
Subject
Patients
Predicate
LOCATION_OF
Object
IMPACT gene
3. IMPACT gene AFFECTS Seizures
Subject
IMPACT gene
Predicate
AFFECTS
Object
Seizures
4. Ambulatory Care Facilities LOCATION_OF Cross-Sectional Studies
Subject
Ambulatory Care Facilities
Predicate
LOCATION_OF
Object
Cross-Sectional Studies
5. American College of Cardiology/American Heart Association Lesion Complexity Score C COEXISTS_WITH Epilepsy
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
COEXISTS_WITH
Object
Epilepsy
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 NEG_COEXISTS_WITH Fit frequency
Subject
COVID-19
Predicate
NEG_COEXISTS_WITH
Object
Fit frequency
8. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
9. Sleeplessness PROCESS_OF Patients
Subject
Sleeplessness
Predicate
PROCESS_OF
Object
Patients
10. Drug Resistant Epilepsy PROCESS_OF Patients
Subject
Drug Resistant Epilepsy
Predicate
PROCESS_OF
Object
Patients
11. Has difficulty doing (qualifier value) PROCESS_OF Patients
Subject
Has difficulty doing (qualifier value)
Predicate
PROCESS_OF
Object
Patients
12. Epilepsy PROCESS_OF Patients
Subject
Epilepsy
Predicate
PROCESS_OF
Object
Patients
13. Patients LOCATION_OF IMPACT gene
Subject
Patients
Predicate
LOCATION_OF
Object
IMPACT gene
14. IMPACT gene AFFECTS Seizures
Subject
IMPACT gene
Predicate
AFFECTS
Object
Seizures
15. Ambulatory Care Facilities LOCATION_OF Cross-Sectional Studies
Subject
Ambulatory Care Facilities
Predicate
LOCATION_OF
Object
Cross-Sectional Studies
16. American College of Cardiology/American Heart Association Lesion Complexity Score C COEXISTS_WITH Epilepsy
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
COEXISTS_WITH
Object
Epilepsy
17. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
18. COVID-19 NEG_COEXISTS_WITH Fit frequency
Subject
COVID-19
Predicate
NEG_COEXISTS_WITH
Object
Fit frequency
19. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
20. Sleeplessness PROCESS_OF Patients
Subject
Sleeplessness
Predicate
PROCESS_OF
Object
Patients
21. Drug Resistant Epilepsy PROCESS_OF Patients
Subject
Drug Resistant Epilepsy
Predicate
PROCESS_OF
Object
Patients
22. Has difficulty doing (qualifier value) PROCESS_OF Patients
Subject
Has difficulty doing (qualifier value)
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

OBJECTIVES:

Collateral damage may occur in epilepsy management during the coronavirus (COVID-19) pandemic. We aimed to establish the impact of this pandemic on epilepsy patients in terms of patient-reported seizure control and emerging symptoms. MATERIALS &

METHODS:

This is a cross-sectional study including consecutive patients assessed by telephone contact in an epilepsy clinic during the first month of confinement. Demographic and clinical characteristics were recorded, and a 19-item questionnaire was systematically completed. Data regarding the impact of confinement, economic effects of the pandemic, and subjective perception of telemedicine were recorded. Additional clinical data were obtained in patients with a COVID-19 diagnosis.

RESULTS:

Two hundred and fifty-five patients were recruited mean age 48.2 ± 19.8 years, 121 (47.5%) women. An increase in seizure frequency was reported by 25 (9.8%) patients. Sixty-eight (26.7%) patients reported confinement-related anxiety, 22 (8.6%) depression, 31 (12.2%) both, and 72 (28.2%) insomnia. Seventy-three (28.6%) patients reported a reduction in economic income. Logistic regression analysis showed that tumor-related epilepsy etiology [OR = 7.36 (95% CI 2.17-24.96)], drug-resistant epilepsy [OR = 3.44 (95% CI 1.19-9.95)], insomnia [OR = 3.25 (95% CI 1.18-8.96)], fear of epilepsy [OR = 3.26 (95% CI 1.09-9.74)], and income reduction [OR = 3.65 (95% CI 1.21-10.95)] were associated with a higher risk of increased seizure frequency. Telemedicine was considered satisfactory by 214 (83.9%) patients. Five patients were diagnosed with COVID-19, with no changes in seizure frequency.

CONCLUSIONS:

The COVID-19 pandemic has effects in epilepsy patients. Patients with tumor-related, drug-resistant epilepsy, insomnia, and economic difficulties are at a higher risk of increased seizure frequency. Telemedicine represents a suitable tool in this setting.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Epilepsy / Symptom Flare Up / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Acta Neurol Scand Year: 2020 Document Type: Article Affiliation country: Ane.13335

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Epilepsy / Symptom Flare Up / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Acta Neurol Scand Year: 2020 Document Type: Article Affiliation country: Ane.13335