Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Protein Sci
; 29(7): 1596-1605, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-71902
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS-CoVs and Middle East Respiratory Syndrome coronavirus (MERS-CoVs), the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies, and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oligonucleotides
/
Viral Nonstructural Proteins
/
Severe acute respiratory syndrome-related coronavirus
/
Endoribonucleases
/
Middle East Respiratory Syndrome Coronavirus
/
Betacoronavirus
Topics:
Vaccines
Language:
English
Journal:
Protein Sci
Journal subject:
Biochemistry
Year:
2020
Document Type:
Article
Affiliation country:
Pro.3873
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