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Novel Coronavirus Disease 2019 (COVID-19) Pneumonia Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section Computed Tomography Features During Recovery.
Han, Xiaoyu; Cao, Yukun; Jiang, Nanchuan; Chen, Yan; Alwalid, Osamah; Zhang, Xin; Gu, Jin; Dai, Meng; Liu, Jie; Zhu, Wanyue; Zheng, Chuansheng; Shi, Heshui.
  • Han X; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Cao Y; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
  • Jiang N; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Chen Y; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
  • Alwalid O; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Zhang X; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
  • Gu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Dai M; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
  • Liu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Zhu W; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
  • Zheng C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People's Republic of China.
  • Shi H; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, The People's Republic of China.
Clin Infect Dis ; 71(15): 723-731, 2020 07 28.
Article in English | MEDLINE | ID: covidwho-719209
ABSTRACT

BACKGROUND:

Our objective was to retrospectively analyze the evolution of clinical features and thin-section computed tomography (CT) imaging of novel coronavirus disease 2019 (COVID-19) pneumonia in 17 discharged patients.

METHODS:

Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and a CT pattern were documented in all patients during the 4 weeks after admission. A CT score was used to evaluate the extent of the disease.

RESULTS:

There were marked improvements of fever, lymphocyte counts, C-reactive proteins, and erythrocyte sedimentation rates within the first 2 weeks after admission. However, the mean CT score rapidly increased from the first to the third week, with a top score of 8.2 obtained in the second week. During the first week, the main CT pattern was ground-glass opacities (GGO; 76.5%). The frequency of GGO (52.9%) decreased in the second week. Consolidation and mixed patterns (47.0%) were noted in the second week. Thereafter, consolidations generally dissipated into GGO, and the frequency of GGO increased in the third week (76.5%) and fourth week (71.4%). Opacities were mainly located in the peripheral (76.5%) and subpleural (47.1%) zones of the lungs; they presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third weeks (58.8%), then showed a reduced extent in fourth week (50%).

CONCLUSIONS:

The progression course of the CT pattern was later than the progression of the clinical parameters within the first 2 weeks after admission; however, there were synchronized improvements in both the clinical and radiologic features in the fourth week.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pneumonia, Viral / Coronavirus Infections Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pneumonia, Viral / Coronavirus Infections Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article