COVID-19 Viral Load in the Severity of and Recovery From Olfactory and Gustatory Dysfunction.
Laryngoscope
; 130(11): 2680-2685, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-720339
ABSTRACT
OBJECTIVES/HYPOTHESIS:
This study investigated olfactory and gustatory dysfunction in the 2020 novel coronavirus disease (COVID-19) patients, and their correlations with viral load evaluation. STUDYDESIGN:
Prospective cross-sectional cohort study.METHODS:
One hundred forty-three symptomatic patients being screened for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were invited to participate. The clinical data of 83 confirmed COVID-19 subjects were collected, with 60 patients who were symptomatic but negative for COVID-19 recruited as controls. The prevalence and severity of and recovery time for olfactory and gustatory dysfunction, and cycle threshold (Ct) values from a SARS-CoV-2 polymerase chain reaction assay of nasopharyngeal and deep throat swabs were collected. Their correlations with Ct values were reported.RESULTS:
Thirty-nine (47.0%) and 36 (43.4%) COVID-19 patients reported olfactory and gustatory dysfunction, respectively. The results of one-way analysis of variance did not show statistically significant relationships between the Ct values and severity of olfactory and gustatory dysfunction (P = .780 and P = .121, respectively). Among the COVID-19 patients who reported smell and taste loss, 28/39 (71.8%) and 30/36 (83.3%) experienced complete recovery, respectively. The mean recovery time was 10.3 ± 8.1 days for olfactory dysfunction and 9.5 ± 6.8 days for gustatory dysfunction. The recovery time was not correlated with the Ct values (Pearson correlation coefficient, smell -0.008, P = .968; taste -0.015, P = .940).CONCLUSIONS:
There is a high prevalence of olfactory and gustatory dysfunction in COVID-19. However, the severity of and recovery from these symptoms have no correlations with the viral load of SARS-CoV-2. LEVEL OF EVIDENCE 4 Laryngoscope, 1302680-2685, 2020.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Taste Disorders
/
Viral Load
/
SARS-CoV-2
/
COVID-19
/
Olfaction Disorders
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
Asia
Language:
English
Journal:
Laryngoscope
Journal subject:
Otolaryngology
Year:
2020
Document Type:
Article
Affiliation country:
Lary.29056
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