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Patients' Attitudes to Unproven Therapies in Treating COVID-19 Merit Evaluation.
Li, Hong-Tian; Cheng, Zhi-Hao; Huang, Yong-Ying; Lv, Xi-Lin; Zhou, Yu-Bo; Dong, Erdan; Liu, Jian-Meng.
  • Li HT; Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, No 38, Xueyuan Road, Haidian District, Beijing 100191, China.
  • Cheng ZH; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
  • Huang YY; Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, No 38, Xueyuan Road, Haidian District, Beijing 100191, China.
  • Lv XL; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
  • Zhou YB; Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, No 38, Xueyuan Road, Haidian District, Beijing 100191, China.
  • Dong E; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
  • Liu JM; Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, No 38, Xueyuan Road, Haidian District, Beijing 100191, China.
Innovation (N Y) ; 1(2): 100028, 2020 08 28.
Article in English | MEDLINE | ID: covidwho-720752
Semantic information from SemMedBD (by NLM)
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3. Experimental drug ADMINISTERED_TO Participant
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ABSTRACT
Since the outbreak of COVID-19, many randomized controlled trials have been launched to test the efficacy of promising treatments. These trials will offer great promise for future treatment. However, a public health emergency calls for a balance between gathering sound evidence and granting therapeutic access to promising trial drugs as widely as possible. In an electronic survey, we found that 3.9% of the participants preferred to receive an unproven trial drug directly in the hypothetical scenario of mild COVID-19 infection. This percentage increased drastically to 31.1% and 54.2% in the hypothetical scenario of severe and extremely severe infection, respectively. Our survey indicates a likelihood of substantial receptivity of trial drugs among actual patients in severe conditions. From the perspective of deontological ethics, a trial can only be approved when potential benefits of the investigational treatment are presumed to outweigh risks, so compassionate or off-label use of investigational therapies merits evaluation.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Controlled clinical trial / Randomized controlled trials Language: English Journal: Innovation (N Y) Year: 2020 Document Type: Article Affiliation country: J.xinn.2020.100028

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Controlled clinical trial / Randomized controlled trials Language: English Journal: Innovation (N Y) Year: 2020 Document Type: Article Affiliation country: J.xinn.2020.100028