Your browser doesn't support javascript.
The Application of Single-Cell RNA Sequencing in Vaccinology.
Noé, Andrés; Cargill, Tamsin N; Nielsen, Carolyn M; Russell, Andrew J C; Barnes, Eleanor.
  • Noé A; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
  • Cargill TN; Peter Medawar Building for Pathogen Research and Oxford NIHR Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, UK.
  • Nielsen CM; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • Russell AJC; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
  • Barnes E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
J Immunol Res ; 2020: 8624963, 2020.
Article in English | MEDLINE | ID: covidwho-721226
ABSTRACT
Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Single-Cell Analysis / Pandemics / Betacoronavirus / Vaccinology / RNA-Seq Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine / Vaccines Limits: Animals / Humans Language: English Journal: J Immunol Res Year: 2020 Document Type: Article Affiliation country: 2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Single-Cell Analysis / Pandemics / Betacoronavirus / Vaccinology / RNA-Seq Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine / Vaccines Limits: Animals / Humans Language: English Journal: J Immunol Res Year: 2020 Document Type: Article Affiliation country: 2020