Can Bioactive Lipid Arachidonic Acid Prevent and Ameliorate COVID-19?

ABSTRACT

It is proposed that the bioactive lipid, arachidonic acid (AA, 204 n-6), can inactivate severe acute respiratory syndrome(SARS-CoV-2), facilitate M1 and M2 macrophage generation, suppress inflammation, prevent vascular endothelial cell damage, and regulate inflammation resolution processes based on the timely formation of prostaglandin E2 (PGE2) and lipoxin A4 (LXA4) based on the context. Thus, AA may be useful both to prevent and manage coronavrus disease-2019(COVID-19).