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Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report.
Paliogiannis, Panagiotis; Zinellu, Angelo; Scano, Valentina; Mulas, Giulia; De Riu, Giacomo; Pascale, Rosa M; Arru, Luigi B; Carru, Ciriaco; Pirina, Pietro; Mangoni, Arduino A; Fois, Alessandro G.
  • Paliogiannis P; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. ppaliogiannis@uniss.it.
  • Zinellu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy. azinellu@uniss.it.
  • Scano V; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. valescano93@gmail.com.
  • Mulas G; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. giulia_mulas@hotmail.it.
  • De Riu G; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. gderiu@uniss.it.
  • Pascale RM; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. patsper@uniss.it.
  • Arru LB; Operative Unit of Hematology, Center for Stem Cell Transplantation, San Francesco Hospital, Nuoro, Italy.
  • Carru C; Department of Biomedical Sciences, University of Sassari, Sassari, Italy. carru@uniss.it.
  • Pirina P; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. pirina@uniss.it.
  • Mangoni AA; Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia. arduino.mangoni@flinders.edu.au.
  • Fois AG; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. agfois@uniss.it.
J Infect Dev Ctries ; 14(7): 685-690, 2020 07 31.
Article in English | MEDLINE | ID: covidwho-721541
ABSTRACT

INTRODUCTION:

Coronavirus disease 19 (COVID-19) is the greatest pandemic in modern history. Laboratory test alterations have been described in COVID-19 patients, but differences with other pneumonias have been poorly investigated to date, especially in Caucasian populations. The aim of this study was to investigate differences and prognostic potential of routine blood tests in a series of Italian patients with COVID-19 and non-COVID-19 interstitial pneumonia.

METHODOLOGY:

Clinical data and routine laboratory tests of a consecutive series of 30 COVID-19 patients and 30 age and sex matched patients with non COVID-19 interstitial pneumonia have been retrospectively collected. Differences in laboratory tests between patients with COVID-19 and non COVID-19 pneumonias have been investigated, as well as differences between COVID-19 survivors and non survivors.

RESULTS:

COVID-19 patients had lower white blood cells, monocytes, neutrophils, and higher platelet counts. In addition, COVID-19 patients showed higher mean platelet volume, lower C reactive protein concentrations, and higher De Ritis ratio. Combined blood cell indexes of systemic inflammation were significantly lower in COVID-19 patients. In further analysis of the COVID-19 group, the neutrophil count, neutrophil to lymphocyte ratio (NLR), derived NLR, systemic inflammation response index and De Ritis ratio, were significantly higher in non survivors than in survivors, while the number of platelets was significantly lower in non survivors.

CONCLUSIONS:

Our study showed several alterations in blood cell populations and indexes in patients with COVID-19 pneumonia in comparison with patients with non COVID-19 pneumonia. Some of these indexes showed promising prognostic abilities. Further studies are necessary to confirm these results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lung Diseases, Interstitial / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dev Ctries Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Jidc.12879

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lung Diseases, Interstitial / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dev Ctries Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Jidc.12879