Immune Response and COVID-19: A mirror image of Sepsis.
Int J Biol Sci
; 16(14): 2479-2489, 2020.
Article
in English
| MEDLINE | ID: covidwho-721623
ABSTRACT
The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered significant threats to public health, in addition to political and social changes. An important number of studies have reported the onset of symptoms compatible with pneumonia accompanied by coagulopathy and lymphocytopenia during COVID-19. Increased cytokine levels, the emergence of acute phase reactants, platelet activation and immune checkpoint expression are some of the biomarkers postulated in this context. As previously observed in prolonged sepsis, T-cell exhaustion due to SARS-CoV-2 and even their reduction in numbers due to apoptosis hinder the response to the infection. In this review, we synthesized the immune changes observed during COVID-19, the role of immune molecules as severity markers for patient stratification and their associated therapeutic options.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Sepsis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Int J Biol Sci
Journal subject:
Biology
Year:
2020
Document Type:
Article
Affiliation country:
Ijbs.48400
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