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Potential Role of Oxygen-Ozone Therapy in Treatment of COVID-19 Pneumonia.
Hernández, Alberto; Viñals, Montserrat; Isidoro, Tomas; Vilás, Francisco.
  • Hernández A; Department of Anesthesiology, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Viñals M; Department of Internal Medicine, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Isidoro T; Department of Surgery, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Vilás F; Department of Surgery, Policlinica Ibiza Hospital, Ibiza, Spain.
Am J Case Rep ; 21: e925849, 2020 Aug 17.
Article in English | MEDLINE | ID: covidwho-721633
Semantic information from SemMedBD (by NLM)
1. Coronavirus Infections CAUSES Pneumonia
Subject
Coronavirus Infections
Predicate
CAUSES
Object
Pneumonia
2. Intubation CAUSES Shock
Subject
Intubation
Predicate
CAUSES
Object
Shock
3. Mechanical ventilation CAUSES Shock
Subject
Mechanical ventilation
Predicate
CAUSES
Object
Shock
4. Pneumonia COEXISTS_WITH Coronavirus Infections
Subject
Pneumonia
Predicate
COEXISTS_WITH
Object
Coronavirus Infections
5. Thrombosis COEXISTS_WITH Coronavirus Infections
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
Coronavirus Infections
6. Organ LOCATION_OF Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Organ
Predicate
LOCATION_OF
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
7. Heart LOCATION_OF Protection
Subject
Heart
Predicate
LOCATION_OF
Object
Protection
8. Thrombophilia AFFECTS Immune System Processes
Subject
Thrombophilia
Predicate
AFFECTS
Object
Immune System Processes
9. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
10. Decreasing PROCESS_OF Patients
Subject
Decreasing
Predicate
PROCESS_OF
Object
Patients
11. Pneumonia COEXISTS_WITH Respiratory Failure
Subject
Pneumonia
Predicate
COEXISTS_WITH
Object
Respiratory Failure
12. Invasive mechanical ventilation NOS NEG_TREATS Patients
Subject
Invasive mechanical ventilation NOS
Predicate
NEG_TREATS
Object
Patients
13. Oxygen Therapy Care TREATS Respiratory Failure
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
Respiratory Failure
14. Oxygen Therapy Care TREATS COVID-19
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
COVID-19
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Oxygen Therapy Care TREATS Patients
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
Patients
17. Respiratory Failure PROCESS_OF Patients
Subject
Respiratory Failure
Predicate
PROCESS_OF
Object
Patients
18. Clinical Trials USES Oxygen Therapy Care
Subject
Clinical Trials
Predicate
USES
Object
Oxygen Therapy Care
19. Coronavirus Infections CAUSES Pneumonia
Subject
Coronavirus Infections
Predicate
CAUSES
Object
Pneumonia
20. Intubation CAUSES Shock
Subject
Intubation
Predicate
CAUSES
Object
Shock
21. Mechanical ventilation CAUSES Shock
Subject
Mechanical ventilation
Predicate
CAUSES
Object
Shock
22. Pneumonia COEXISTS_WITH Coronavirus Infections
Subject
Pneumonia
Predicate
COEXISTS_WITH
Object
Coronavirus Infections
23. Thrombosis COEXISTS_WITH Coronavirus Infections
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
Coronavirus Infections
24. Organ LOCATION_OF Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Organ
Predicate
LOCATION_OF
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
25. Heart LOCATION_OF Protection
Subject
Heart
Predicate
LOCATION_OF
Object
Protection
26. Thrombophilia AFFECTS Immune System Processes
Subject
Thrombophilia
Predicate
AFFECTS
Object
Immune System Processes
27. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
28. Decreasing PROCESS_OF Patients
Subject
Decreasing
Predicate
PROCESS_OF
Object
Patients
29. Pneumonia COEXISTS_WITH Respiratory Failure
Subject
Pneumonia
Predicate
COEXISTS_WITH
Object
Respiratory Failure
30. Invasive mechanical ventilation NOS NEG_TREATS Patients
Subject
Invasive mechanical ventilation NOS
Predicate
NEG_TREATS
Object
Patients
31. Oxygen Therapy Care TREATS Respiratory Failure
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
Respiratory Failure
32. Oxygen Therapy Care TREATS COVID-19
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
COVID-19
33. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
34. Oxygen Therapy Care TREATS Patients
Subject
Oxygen Therapy Care
Predicate
TREATS
Object
Patients
35. Respiratory Failure PROCESS_OF Patients
Subject
Respiratory Failure
Predicate
PROCESS_OF
Object
Patients
36. Clinical Trials USES Oxygen Therapy Care
Subject
Clinical Trials
Predicate
USES
Object
Oxygen Therapy Care
ABSTRACT
BACKGROUND Pneumonia caused by coronavirus originated in Wuhan, China in late 2019 and has spread around the world, becoming a pandemic. Many patients deteriorate rapidly and require intubation and mechanical ventilation, which is causing the collapse of healthcare systems in many countries. Coronavirus infection is associated with extensive lung inflammation and microvascular thrombosis, which can result in hypoxia. It can also cause severe and lasting harm in other organs, including the heart and kidneys. At present, there is no proven and efficacious treatment for this new disease. Consequently, there is a growing tendency to use novel methods. Ozone therapy consists of administration of a mixture of oxygen and ozone (a molecule consisting of 3 oxygen atoms). The potential benefits of this therapy include reduced tissue hypoxia, decreased hypercoagulability, renal and heart protection, modulated immune function, improved phagocytic function, and impaired viral replication. CASE REPORT We report rapidly improved hypoxia with associated decreases in inflammatory markers and D-dimer immediately after 1-4 sessions of oxygen-ozone (O2-O3) therapy in 3 patients with COVID-19 pneumonia who presented with respiratory failure. Invasive mechanical ventilation was not required in these 3 patients. All patients were discharged home on days 3-4 after O2-O3 therapy. CONCLUSIONS O2-O3 therapy appears to be an effective therapy for COVID-19 patients with severe respiratory failure. Large controlled clinical trials are required to study the efficacy and safety of using O2-O3 therapy compared with the standard supportive case in patients with COVID-19 in terms of the need for invasive ventilation and length of hospital and intensive care unit stays.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Subject: Oxygen / Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study Language: English Journal: Am J Case Rep Clinical aspect: Etiology / Prediction / Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Subject: Oxygen / Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study Language: English Journal: Am J Case Rep Clinical aspect: Etiology / Prediction / Prognosis Year: 2020
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