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ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity.
Ali, Fedaa; Elserafy, Menattallah; Alkordi, Mohamed H; Amin, Muhamed.
  • Ali F; Department of Sciences, University College Groningen, University of Groningen, Hoendiepskade 23/24, 9718, BG Groningen, Netherlands.
  • Elserafy M; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt.
  • Alkordi MH; Center for Materials Science, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt.
  • Amin M; Department of Sciences, University College Groningen, University of Groningen, Hoendiepskade 23/24, 9718, BG Groningen, Netherlands.
Biochem Biophys Rep ; 24: 100798, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-722016
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ABSTRACT
The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Journal: Biochem Biophys Rep Year: 2020 Document Type: Article Affiliation country: J.bbrep.2020.100798

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Journal: Biochem Biophys Rep Year: 2020 Document Type: Article Affiliation country: J.bbrep.2020.100798