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Candesartan could ameliorate the COVID-19 cytokine storm.
Elkahloun, Abdel G; Saavedra, Juan M.
  • Elkahloun AG; Comparative Genomics and Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: abdel@mail.nih.gov.
  • Saavedra JM; Department of Pharmacology and Physiology, Georgetown University Medical Center, SE402 Med/Dent, 3900 Reservoir Road, Washington, DC 20057, USA. Electronic address: juan.saavedra@georgetown.edu.
Biomed Pharmacother ; 131: 110653, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-722385
ABSTRACT

BACKGROUND:

Angiotensin receptor blockers (ARBs) reducing inflammation and protecting lung and brain function, could be of therapeutic efficacy in COVID-19 patients.

METHODS:

Using GSEA, we compared our previous transcriptome analysis of neurons injured by glutamate and treated with the ARB Candesartan (GSE67036) with transcriptional signatures from SARS-CoV-2 infected primary human bronchial epithelial cells (NHBE) and lung postmortem (GSE147507), PBMC and BALF samples (CRA002390) from COVID-19 patients.

RESULTS:

Hundreds of genes upregulated in SARS-CoV-2/COVID-19 transcriptomes were similarly upregulated by glutamate and normalized by Candesartan. Gene Ontology analysis revealed expression profiles with greatest significance and enrichment, including proinflammatory cytokine and chemokine activity, the NF-kappa B complex, alterations in innate and adaptive immunity, with many genes participating in the COVID-19 cytokine storm.

CONCLUSIONS:

There are similar injury mechanisms in SARS-CoV-2 infection and neuronal injury, equally reduced by ARB treatment. This supports the hypothesis of a therapeutic role for ARBs, ameliorating the COVID-19 cytokine storm.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tetrazoles / Benzimidazoles / Coronavirus Infections / Angiotensin II Type 1 Receptor Blockers / Cytokine Release Syndrome Topics: Long Covid Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tetrazoles / Benzimidazoles / Coronavirus Infections / Angiotensin II Type 1 Receptor Blockers / Cytokine Release Syndrome Topics: Long Covid Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article