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Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19.
Guervilly, Christophe; Burtey, Stephane; Sabatier, Florence; Cauchois, Raphaël; Lano, Guillaume; Abdili, Evelyne; Daviet, Florence; Arnaud, Laurent; Brunet, Philippe; Hraiech, Sami; Jourde-Chiche, Noémie; Koubi, Marie; Lacroix, Romaric; Pietri, Léa; Berda, Yaël; Robert, Thomas; Degioanni, Clara; Velier, Mélanie; Papazian, Laurent; Kaplanski, Gilles; Dignat-George, Françoise.
  • Guervilly C; Medical Intensive Care Unit, North Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Burtey S; Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France.
  • Sabatier F; Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Cauchois R; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Lano G; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Abdili E; Laboratory of Hematology and Vascular Biology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Daviet F; Cell Therapy Unit, INSERM CBT1409, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Arnaud L; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Brunet P; Department of Internal Medicine and Clinical Immunology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Hraiech S; Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Jourde-Chiche N; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Koubi M; Laboratory of Hematology and Vascular Biology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Lacroix R; Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Pietri L; Laboratory of Hematology and Vascular Biology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Berda Y; Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Robert T; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Degioanni C; Medical Intensive Care Unit, North Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Velier M; Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France.
  • Papazian L; Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
  • Kaplanski G; Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France.
  • Dignat-George F; Department of Internal Medicine and Clinical Immunology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
J Infect Dis ; 222(11): 1789-1793, 2020 Nov 09.
Article in English | MEDLINE | ID: covidwho-722491
ABSTRACT
Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis