Your browser doesn't support javascript.
Environmental contamination in the isolation rooms of COVID-19 patients with severe pneumonia requiring mechanical ventilation or high-flow oxygen therapy.
Ahn, J Y; An, S; Sohn, Y; Cho, Y; Hyun, J H; Baek, Y J; Kim, M H; Jeong, S J; Kim, J H; Ku, N S; Yeom, J-S; Smith, D M; Lee, H; Yong, D; Lee, Y-J; Kim, J W; Kim, H R; Hwang, J; Choi, J Y.
  • Ahn JY; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • An S; School of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
  • Sohn Y; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Cho Y; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Hyun JH; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Baek YJ; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim MH; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Jeong SJ; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim JH; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Ku NS; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Yeom JS; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Smith DM; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Lee H; Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Yong D; Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee YJ; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim JW; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim HR; School of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
  • Hwang J; School of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.
  • Choi JY; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: seran@yuhs.ac.
J Hosp Infect ; 106(3): 570-576, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-723894
Semantic information from SemMedBD (by NLM)
1. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
2. Mechanical ventilation USES Suction system
Subject
Mechanical ventilation
Predicate
USES
Object
Suction system
3. Real-Time Polymerase Chain Reaction DIAGNOSES 2019 novel coronavirus
Subject
Real-Time Polymerase Chain Reaction
Predicate
DIAGNOSES
Object
2019 novel coronavirus
4. Mechanical ventilation ADMINISTERED_TO Patients
Subject
Mechanical ventilation
Predicate
ADMINISTERED_TO
Object
Patients
5. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
6. Mechanical ventilation USES Suction system
Subject
Mechanical ventilation
Predicate
USES
Object
Suction system
7. Real-Time Polymerase Chain Reaction DIAGNOSES 2019 novel coronavirus
Subject
Real-Time Polymerase Chain Reaction
Predicate
DIAGNOSES
Object
2019 novel coronavirus
8. Mechanical ventilation ADMINISTERED_TO Patients
Subject
Mechanical ventilation
Predicate
ADMINISTERED_TO
Object
Patients
ABSTRACT

BACKGROUND:

Identifying the extent of environmental contamination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for infection control and prevention. The extent of environmental contamination has not been fully investigated in the context of severe coronavirus disease (COVID-19) patients.

AIM:

To investigate environmental SARS-CoV-2 contamination in the isolation rooms of severe COVID-19 patients requiring mechanical ventilation or high-flow oxygen therapy.

METHODS:

Environmental swab samples and air samples were collected from the isolation rooms of three COVID-19 patients with severe pneumonia. Patients 1 and 2 received mechanical ventilation with a closed suction system, while patient 3 received high-flow oxygen therapy and non-invasive ventilation. Real-time reverse transcription-polymerase chain reaction (rRT-PCR) was used to detect SARS-CoV-2; viral cultures were performed for samples not negative on rRT-PCR.

FINDINGS:

Of the 48 swab samples collected in the rooms of patients 1 and 2, only samples from the outside surfaces of the endotracheal tubes tested positive for SARS-CoV-2 by rRT-PCR. However, in patient 3's room, 13 of the 28 environmental samples (fomites, fixed structures, and ventilation exit on the ceiling) showed positive results. Air samples were negative for SARS-CoV-2. Viable viruses were identified on the surface of the endotracheal tube of patient 1 and seven sites in patient 3's room.

CONCLUSION:

Environmental contamination of SARS-CoV-2 may be a route of viral transmission. However, it might be minimized when patients receive mechanical ventilation with a closed suction system. These findings can provide evidence for guidelines for the safe use of personal protective equipment.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pneumonia, Viral / Respiration, Artificial / Patients' Rooms / Decontamination / Practice Guidelines as Topic / Coronavirus Infections / Environmental Pollution / Hyperbaric Oxygenation Type of study: Clinical Practice Guide / Prognostic study Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pneumonia, Viral / Respiration, Artificial / Patients' Rooms / Decontamination / Practice Guidelines as Topic / Coronavirus Infections / Environmental Pollution / Hyperbaric Oxygenation Type of study: Clinical Practice Guide / Prognostic study Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article