The Effect of Atrial Septal Defect in the Treatment of ARDS with Left Ventricular Dysfunction Simulating Severe COVID-19.
Heart Surg Forum
; 23(5): E574-E578, 2020 Aug 05.
Article
in English
| MEDLINE | ID: covidwho-724315
ABSTRACT
OBJECTIVE:
To explore the effect of atrial septal defect (ASD) and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the treatment of ARDS combined with left ventricular dysfunction (LVD) to find a new effective method for treating severe COVID-19 patients. MATERIALS ANDMETHODS:
Five large animal ARDS models of sheep were established by intravenous injection of Lipopolysaccharide. ASD was made under general anesthesia and VA-ECMO was simulated by extracorporeal circulation machine. The oxygenation of peripheral blood, systemic circulation, and cardiac function were observed under conditions of closed and opened ASD, and the significance of ASD shunt in improving cardiopulmonary function was evaluated.RESULTS:
With ASD closed, the atrial shunts disappeared, the peripheral artery pressure of oxygen(PaO2) 141.2±21.4mmHg, the oxygenation index (PaO2/FiO2) 353.0±53.5, the mean blood pressure (MAP) 49.3±13.5 mmHg, the heart was full; with ASD opened, the left-to-right shunt was observed, PaO2 169.3±18.9mmHg, PaO2/FiO2 423.3±47.3, MAP 68.2±16.1 mmHg, the range of cardiac motion significantly increased, heart beat was powerful, and systemic circulation significantly improved. Statistical analysis showed that there were significant differences between opened and closed ASD (P < .01).CONCLUSION:
ASD plus VA-ECMO is an effective method for the treatment of ARDS combined with LVD, which is the main cause of death in severe COVID-19 patients. However, further clinical validation is needed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Respiratory Distress Syndrome
/
Extracorporeal Membrane Oxygenation
/
Coronavirus Infections
/
Ventricular Dysfunction, Left
/
Betacoronavirus
/
Heart Septal Defects, Atrial
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Animals
Language:
English
Journal:
Heart Surg Forum
Journal subject:
Cardiology
Year:
2020
Document Type:
Article
Affiliation country:
Hsf.3077
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