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Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study from the Cincinnati SARS-CoV-2 Emergency Department Cohort.
Henry, Brandon Michael; Benoit, Justin Lee; Benoit, Stefanie; Pulvino, Christina; Berger, Brandon A; Olivera, Maria Helena Santos de; Crutchfield, Christopher A; Lippi, Giuseppe.
  • Henry BM; Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Benoit JL; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.
  • Benoit S; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Pulvino C; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA.
  • Berger BA; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.
  • Olivera MHS; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.
  • Crutchfield CA; Department of Statistics, Federal University of Parana, Curitiba 80060-000, Brazil.
  • Lippi G; Department of Pathology & Laboratory Medicine, University of Cincinnati, College of Medicine, OH 45219, USA.
Diagnostics (Basel) ; 10(9)2020 Aug 21.
Article in English | MEDLINE | ID: covidwho-724633
ABSTRACT
Since previous evidence has demonstrated that red blood cell distribution width (RDW) may be a useful prognostic parameter in many critical illnesses and infectious diseases, we investigated the utility of RDW for monitoring patients with coronavirus disease 2019 (COVID-19). The study population consisted of 49 COVID-19 patients, including 16 (32.6%) with severe illness, 12 (24.5%) with severe acute kidney injury (AKI), and 8 (16.3%) requiring renal replacement therapy (RRT). The predictive value of blood tests, performed during emergency department evaluation, was then addressed. A progressive increase of RDW was observed with advancing COVID-19 severity. The area under the curve (AUC) of RDW was 0.73 for predicting severe illness, 0.80 for severe AKI, and 0.83 for RRT, respectively. In multivariate analysis, elevated RDW was associated with 9-fold and 16-fold increased odds of severe COVID-19 and AKI, respectively. The results of this study suggest that RDW should be part of routine laboratory assessment and monitoring of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Diagnostics10090618

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Diagnostics10090618