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Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome.
Bouadma, Lila; Wiedemann, Aurélie; Patrier, Juliette; Surénaud, Mathieu; Wicky, Paul-Henri; Foucat, Emile; Diehl, Jean-Luc; Hejblum, Boris P; Sinnah, Fabrice; de Montmollin, Etienne; Lacabaratz, Christine; Thiébaut, Rodolphe; Timsit, J F; Lévy, Yves.
  • Bouadma L; APHP- Hôpital Bichat - Médecine Intensive et Réanimation des Maladies Infectieuses, Paris, France.
  • Wiedemann A; UMR 1137 - IAME Team 5 - DeSCID: Decision Sciences in Infectious Diseases, Control and Care, Inserm/Univ Paris Diderot, Sorbonne Paris Cité, Paris, France.
  • Patrier J; Vaccine Research Institute, Faculté de Médecine, INSERM U955, Université Paris-Est Créteil, Créteil, France.
  • Surénaud M; APHP- Hôpital Bichat - Médecine Intensive et Réanimation des Maladies Infectieuses, Paris, France.
  • Wicky PH; Vaccine Research Institute, Faculté de Médecine, INSERM U955, Université Paris-Est Créteil, Créteil, France.
  • Foucat E; APHP- Hôpital Bichat - Médecine Intensive et Réanimation des Maladies Infectieuses, Paris, France.
  • Diehl JL; Vaccine Research Institute, Faculté de Médecine, INSERM U955, Université Paris-Est Créteil, Créteil, France.
  • Hejblum BP; APHP, Hôpital Georges Pompidou, Médecine Intensive Reanimation, Paris, France.
  • Sinnah F; Univ. Bordeaux, Department of Public Health, Inserm Bordeaux Population Health Research Centre, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI), Créteil, France.
  • de Montmollin E; APHP- Hôpital Bichat - Médecine Intensive et Réanimation des Maladies Infectieuses, Paris, France.
  • Lacabaratz C; APHP- Hôpital Bichat - Médecine Intensive et Réanimation des Maladies Infectieuses, Paris, France.
  • Thiébaut R; Vaccine Research Institute, Faculté de Médecine, INSERM U955, Université Paris-Est Créteil, Créteil, France.
  • Timsit JF; Univ. Bordeaux, Department of Public Health, Inserm Bordeaux Population Health Research Centre, Inria SISTM, UMR 1219, Vaccine Research Institute (VRI), Créteil, France.
  • Lévy Y; CHU Bordeaux, Bordeaux, France.
J Clin Immunol ; 40(8): 1082-1092, 2020 11.
Article in English | MEDLINE | ID: covidwho-724903
ABSTRACT
We report a longitudinal analysis of the immune response associated with a fatal case of COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2-3-fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a pro-inflammatory cytokine storm, Th1 and Th2 activation, and markers of T cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response. The investigation was conducted as part of an overall French clinical cohort assessing patients with COVID-19 and registered in clinicaltrials.gov under the following number NCT04262921.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome / Multiple Organ Failure Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Long Covid Country/Region as subject: Europa Language: English Journal: J Clin Immunol Year: 2020 Document Type: Article Affiliation country: S10875-020-00839-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome / Multiple Organ Failure Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Long Covid Country/Region as subject: Europa Language: English Journal: J Clin Immunol Year: 2020 Document Type: Article Affiliation country: S10875-020-00839-x