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Establishment of a Pediatric COVID-19 Biorepository: Unique Considerations and Opportunities for Studying the Impact of the COVID-19 Pandemic on Children.
Lima, Rosiane; Gootkind, Elizabeth; Flor, Denis De La; Yockey, Laura; Bordt, Evan; D'Avino, Paolo; Ning, Shen; Heath, Katerina; Harding, Katherine; Zois, Jaclyn; Park, Grace; Hardcastle, Margot; Grinke, Kathleen A; Grimmel, Sheila; Forde, Pamela J; Davidson, Susan P; Hall, Kathryn E; Neilan, Anne; Matute, Juan D; Lerou, Paul H; Fasano, Alessio; Shui, Jessica E; Edlow, Andrea G; Yonker, Lael M.
  • Lima R; Massachusetts General Hospital.
  • Gootkind E; Massachusetts General Hospital.
  • Flor D; Massachusetts General Hospital.
  • Yockey L; Massachusetts General Hospital.
  • Bordt E; Massachusetts General Hospital.
  • D'Avino P; Massachusetts General Hospital.
  • Ning S; Massachusetts General Hospital.
  • Heath K; Massachusetts General Hospital.
  • Harding K; Massachusetts General Hospital.
  • Zois J; Massachusetts General Hospital.
  • Park G; Massachusetts General Hospital.
  • Hardcastle M; Massachusetts General Hospital.
  • Grinke KA; Massachusetts General Hospital.
  • Grimmel S; Massachusetts General Hospital.
  • Forde PJ; Massachusetts General Hospital.
  • Davidson SP; Massachusetts General Hospital.
  • Hall KE; Massachusetts General Hospital.
  • Neilan A; Massachusetts General Hospital.
  • Matute JD; Massachusetts General Hospital.
  • Lerou PH; Massachusetts General Hospital.
  • Fasano A; Massachusetts General Hospital.
  • Shui JE; Massachusetts General Hospital.
  • Edlow AG; Massachusetts General Hospital.
  • Yonker LM; Massachusetts General Hospital.
Res Sq ; 2020 Aug 10.
Article in English | MEDLINE | ID: covidwho-724933
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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Semantic information from SemMedBD (by NLM)
1. COVID-19 AFFECTS Child
Subject
COVID-19
Predicate
AFFECTS
Object
Child
2. Communicable Diseases CAUSES Disease
Subject
Communicable Diseases
Predicate
CAUSES
Object
Disease
3. Severe Acute Respiratory Syndrome PROCESS_OF Child
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Child
4. Severe Acute Respiratory Syndrome COEXISTS_WITH COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
5. Asymptomatic PROCESS_OF Child
Subject
Asymptomatic
Predicate
PROCESS_OF
Object
Child
6. Infected PROCESS_OF Mother (person)
Subject
Infected
Predicate
PROCESS_OF
Object
Mother (person)
7. Hospitals LOCATION_OF Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Study
8. Urgent Care Clinic/Center LOCATION_OF Study
Subject
Urgent Care Clinic/Center
Predicate
LOCATION_OF
Object
Study
9. Fetus LOCATION_OF IMPACT gene
Subject
Fetus
Predicate
LOCATION_OF
Object
IMPACT gene
10. answer questions AFFECTS viral transmission
Subject
answer questions
Predicate
AFFECTS
Object
viral transmission
11. Immune response PROCESS_OF Child
Subject
Immune response
Predicate
PROCESS_OF
Object
Child
12. COVID-19 AFFECTS Child
Subject
COVID-19
Predicate
AFFECTS
Object
Child
13. Communicable Diseases CAUSES Disease
Subject
Communicable Diseases
Predicate
CAUSES
Object
Disease
14. Severe Acute Respiratory Syndrome PROCESS_OF Child
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Child
15. Severe Acute Respiratory Syndrome COEXISTS_WITH COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
16. Asymptomatic PROCESS_OF Child
Subject
Asymptomatic
Predicate
PROCESS_OF
Object
Child
17. Infected PROCESS_OF Mother (person)
Subject
Infected
Predicate
PROCESS_OF
Object
Mother (person)
18. Hospitals LOCATION_OF Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Study
19. Urgent Care Clinic/Center LOCATION_OF Study
Subject
Urgent Care Clinic/Center
Predicate
LOCATION_OF
Object
Study
20. Fetus LOCATION_OF IMPACT gene
Subject
Fetus
Predicate
LOCATION_OF
Object
IMPACT gene
21. answer questions AFFECTS viral transmission
Subject
answer questions
Predicate
AFFECTS
Object
viral transmission
22. Immune response PROCESS_OF Child
Subject
Immune response
Predicate
PROCESS_OF
Object
Child
ABSTRACT

Background:

COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clinically apparent, collecting high-quality biospecimens from infants, children and adolescents in a standardized manner during the COVID-19 pandemic is essential to establish a biologic understanding of the disease in the pediatric population. This biorepository enables pediatric centers world-wide to collect samples in a standardized manner to drive forward our understanding of COVID-19 by addressing specific pediatric and neonatal COVID-19-related questions.

Methods:

A broad study was implemented with strategic enrollment guidelines to include patients seen in urgent care clinics and hospital settings, neonates born to SARS-CoV-2 infected mothers, and asymptomatic children. The methodology described here, details the importance of establishing collaborations between the clinical and research teams to harmonize protocols for patient recruitment and sample collection, processing and storage.

Results:

Considerations and challenges facing enrollment of neonatal and pediatric cohorts are described. A roadmap is laid out for successful collection, processing, storage and database management of multiple pediatric samples such as blood, nasopharyngeal and oropharyngeal swabs, sputum, saliva, tracheal aspirates, stool, and urine. Using this methodology, we enrolled 327 participants, who provided a total of 972 biospecimens.

Conclusions:

Pediatric biospecimens will be key in answering questions relating to viral transmission by children, differences between pediatric and adult viral susceptibility, and, immune responses, the impact of maternal SARS-CoV-2 infection on fetal development, and factors driving the Multisystem Inflammatory Syndrome in Children. The specimens in this biorepository will allow necessary comparative studies between children and adults, help determine the accuracy of current pediatric viral testing techniques, in addition to, understanding neonatal exposure to SARS-CoV-2 infection and disease abnormalities. The successful establishment of a pediatric biorepository is critical to provide insight into disease pathogenesis, and subsequently, develop future treatment and vaccination strategies.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2020 Document Type: Article