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Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development.
Samrat, Subodh Kumar; Tharappel, Anil M; Li, Zhong; Li, Hongmin.
  • Samrat SK; Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.
  • Tharappel AM; Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.
  • Li Z; Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.
  • Li H; Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, 1 University Place, Rensselaer, NY 12144, USA. Electronic address: Hongmin.li@health.ny.gov.
Virus Res ; 288: 198141, 2020 10 15.
Article in English | MEDLINE | ID: covidwho-725473
ABSTRACT
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are infected, and over 781,135 people have died due to this deadly virus. In the USA alone, over 5,482,602 people are currently infected, and more than 171,823 people have died. SARS-CoV-2 has shown a higher infectivity rate and a more extended incubation period as compared to previous coronaviruses. SARS-CoV-2 binds much more strongly than SARS-CoV to the same host receptor, angiotensin-converting enzyme 2 (ACE2). Previously, several methods to develop a vaccine against SARS-CoV or MERS-CoV have been tried with limited success. Since SARS-CoV-2 uses the spike (S) protein for entry to the host cell, it is one of the most preferred targets for making vaccines or therapeutics against SARS-CoV-2. In this review, we have summarised the characteristics of the S protein, as well as the different approaches being used for the development of vaccines and/or therapeutics based on the S protein.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.198141

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.198141