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A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection.
Sharps, Megan C; Hayes, Dexter J L; Lee, Stacey; Zou, Zhiyong; Brady, Chloe A; Almoghrabi, Yousef; Kerby, Alan; Tamber, Kajal K; Jones, Carolyn J; Adams Waldorf, Kristina M; Heazell, Alexander E P.
  • Sharps MC; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK. Electronic address: megan.sharps@manchester.ac.uk.
  • Hayes DJL; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Lee S; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK; Division of Pharmacy and Optometry, Faculty of Biology, Medicine & Health, University of Manchester, UK.
  • Zou Z; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Brady CA; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Almoghrabi Y; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Kerby A; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Tamber KK; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Jones CJ; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK.
  • Adams Waldorf KM; Department of Obstetrics & Gynecology, University of Washington, Seattle, USA.
  • Heazell AEP; Tommy's Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine & Health, 5th Floor St. Mary's Hospital, University of Manchester, Manchester, UK; St. Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Placenta ; 101: 13-29, 2020 11.
Article in English | MEDLINE | ID: covidwho-725549
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, was first identified after a cluster of cases in Wuhan, China in December 2019. Whether vertical transmission or placental pathology might occur following maternal infection during pregnancy remains unknown. This review aimed to summarise all studies that examined the placenta or neonates following infection with SARS-CoV-2, or closely related highly pathogenic coronavirus (SARS-CoV-1, or the Middle East respiratory syndrome coronavirus (MERS-CoV)). Structured literature searches found 50 studies that met the inclusion criteria. Twenty studies reported placental histopathology findings in third trimester placentas following maternal SARS-CoV-2 infection. Using the Amsterdam Consensus criteria to categorise the histopathology results, evidence of both fetal vascular malperfusion (35.3% of cases; 95% Confidence Interval (CI) 27.7-43.0%) and maternal vascular malperfusion (46% of cases; 95% CI 38.0-54.0%) were reported, along with evidence of inflammation in the placentas (villitis 8.7% cases, intervillositis 5.3% of cases, chorioamnionitis 6% of cases). The placental pathologies observed in SARS-CoV-2 were consistent with findings following maternal SARS-CoV-1 infection. Of those tested, a minority of neonates (2%) and placental samples tested positive for SARS-CoV-2 infection (21%). Limited conclusions can be drawn about the effect of maternal SARS-CoV-2 infection on placental pathology as most lack control groups and the majority of reports followed third trimester infection. Collaboration to maximise the number of samples examined will increase the reliability and generalisability of findings. A better understanding of the association between maternal SARS-CoV-2 infection and placental pathology will inform maternity care during the coronavirus pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta / Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Placenta Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta / Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Placenta Year: 2020 Document Type: Article