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Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.
Xie, Jianfeng; Wu, Wenjuan; Li, Shusheng; Hu, Yu; Hu, Ming; Li, Jinxiu; Yang, Yi; Huang, Tingrong; Zheng, Kun; Wang, Yishan; Kang, Hanyujie; Huang, Yingzi; Jiang, Li; Zhang, Wei; Zhong, Ming; Sang, Ling; Zheng, Xia; Pan, Chun; Zheng, Ruiqiang; Li, Xuyan; Tong, Zhaohui; Qiu, Haibo; Du, Bin.
  • Xie J; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
  • Wu W; Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071, China.
  • Li S; Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Hu Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Hu M; Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan, China.
  • Li J; Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen, China.
  • Yang Y; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
  • Huang T; Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000, China.
  • Zheng K; Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000, China.
  • Wang Y; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
  • Kang H; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
  • Huang Y; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
  • Jiang L; Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
  • Zhang W; Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025, China.
  • Zhong M; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
  • Sang L; Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  • Zheng X; Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
  • Pan C; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
  • Zheng R; Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001, China.
  • Li X; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
  • Tong Z; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. tongzhaohuicy@sina.com.
  • Qiu H; Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. haiboq2000@163.com.
  • Du B; Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730, China. dubin98@gmail.com.
Intensive Care Med ; 46(10): 1863-1872, 2020 10.
Article in English | MEDLINE | ID: covidwho-725842
Semantic information from SemMedBD (by NLM)
1. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
2. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
3. Respiratory Failure PRECEDES Shock
Subject
Respiratory Failure
Predicate
PRECEDES
Object
Shock
4. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
Object
Patients
5. Single organ dysfunction PROCESS_OF Patients
Subject
Single organ dysfunction
Predicate
PROCESS_OF
Object
Patients
6. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
7. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
8. Respiratory Failure PRECEDES Shock
Subject
Respiratory Failure
Predicate
PRECEDES
Object
Shock
9. risk factors PROCESS_OF Patients
Subject
risk factors
Predicate
PROCESS_OF
Object
Patients
10. Single organ dysfunction PROCESS_OF Patients
Subject
Single organ dysfunction
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

PURPOSE:

An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.

METHODS:

We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.

RESULTS:

Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO2/FiO2 level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19.

CONCLUSION:

In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Critical Illness / Coronavirus Infections / Intensive Care Units Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Intensive Care Med Year: 2020 Document Type: Article Affiliation country: S00134-020-06211-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Critical Illness / Coronavirus Infections / Intensive Care Units Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Intensive Care Med Year: 2020 Document Type: Article Affiliation country: S00134-020-06211-2