Your browser doesn't support javascript.
Group Testing for Severe Acute Respiratory Syndrome- Coronavirus 2 to Enable Rapid Scale-up of Testing and Real-Time Surveillance of Incidence.
Pilcher, Christopher D; Westreich, Daniel; Hudgens, Michael G.
  • Pilcher CD; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Westreich D; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Hudgens MG; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Infect Dis ; 222(6): 903-909, 2020 08 17.
Article in English | MEDLINE | ID: covidwho-726096
ABSTRACT
High-throughput molecular testing for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) may be enabled by group testing in which pools of specimens are screened, and individual specimens tested only after a pool tests positive. Several laboratories have recently published examples of pooling strategies applied to SARS-CoV-2 specimens, but overall guidance on efficient pooling strategies is lacking. Therefore we developed a model of the efficiency and accuracy of specimen pooling algorithms based on available data on SAR-CoV-2 viral dynamics. For a fixed number of tests, we estimate that programs using group testing could screen 2-20 times as many specimens compared with individual testing, increase the total number of true positive infections identified, and improve the positive predictive value of results. We compare outcomes that may be expected in different testing situations and provide general recommendations for group testing implementation. A free, publicly-available Web calculator is provided to help inform laboratory decisions on SARS-CoV-2 pooling algorithms.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Specimen Handling / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Specimen Handling / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis