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Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents.
Su, Li; Tu, Ye; Kong, De-Pei; Chen, Da-Gui; Zhang, Chen-Xi; Zhang, Wan-Nian; Zhuang, Chun-Lin; Wang, Zhi-Bin.
  • Su L; Institute of Translational Medicine, Shanghai University, Shanghai, China.
  • Tu Y; Department of Medicine, Shanghai East Hospital, Tongji University, 200120, Shanghai, China.
  • Kong DP; Institute of Translational Medicine, Shanghai University, Shanghai, China.
  • Chen DG; Institute of Translational Medicine, Shanghai University, Shanghai, China.
  • Zhang CX; Institute of Translational Medicine, Shanghai University, Shanghai, China.
  • Zhang WN; School of Pharmacy, Second Military Medical University, 200433, Shanghai, China; School of Pharmacy, Ningxia Medical University, 750004, Yinchuan, China.
  • Zhuang CL; School of Pharmacy, Second Military Medical University, 200433, Shanghai, China; School of Pharmacy, Ningxia Medical University, 750004, Yinchuan, China. Electronic address: zclnathan@163.com.
  • Wang ZB; School of Pharmacy, Second Military Medical University, 200433, Shanghai, China. Electronic address: methyl@smmu.edu.cn.
Biomed Pharmacother ; 131: 110643, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-726408
ABSTRACT
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate CSS, entecavir and imipenem were identified to reduce TNF-α using a LPS-induced macrophage model from the anti-infective drug library. Entecavir and imipenem efficiently suppressed the release of inflammatory cytokines by partly intervention of NF-κB activity. The acute lung injury was also alleviated and the survival time was prolonged in mice. In addition, entecavir and imipenem inhibited the release of TNF-α and IL-10 in human peripheral blood mononuclear cells (hPBMCs). Collectively, we proposed that entecavir and imipenem might be candidates for the treatment of CSS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Imipenem / Coronavirus Infections / Cytokine Release Syndrome / Guanine Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans / Male Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110643

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Imipenem / Coronavirus Infections / Cytokine Release Syndrome / Guanine Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans / Male Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110643