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ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19.
Dong, Mengzhen; Zhang, Jie; Ma, Xuefeng; Tan, Jie; Chen, Lizhen; Liu, Shousheng; Xin, Yongning; Zhuang, Likun.
  • Dong M; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Zhang J; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Ma X; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Tan J; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Chen L; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Liu S; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
  • Xin Y; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China. Electronic address: xinyongning9812@163.com.
  • Zhuang L; Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Institute of Hepatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Digestive Disease Key Laboratory of Qingdao, Qingdao, China. Electronic address: zlk0823@163.com.
Biomed Pharmacother ; 131: 110678, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-726410
ABSTRACT
At the end of 2019, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Currently, it is breaking out globally and posing a serious threat to public health. The typically clinical characteristics of COVID-19 patients were fever and respiratory symptoms, and a proportion of patients were accompanied by extrapulmonary symptoms including cardiac injury, kidney injury, liver injury, digestive tract injury, and neurological symptoms. Angiotensin converting enzyme 2 (ACE2) has been proven to be a major receptor for SARS-CoV-2 and could mediate virus entry into cells. And transmembrane protease serine 2 (TMPRSS2) could cleave the spike (S) protein of SARS-CoV-2, which facilitates the fusion of SARS-CoV-2 and cellular membranes. The mRNA expressions of both ACE2 and TMPRSS2 were observed in the heart, digestive tract, liver, kidney, brain and other organs. SARS-CoV-2 may have a capacity to infect extrapulmonary organs due to the expressions of ACE2 and TMPRSS2 in the cells and tissues of these organs. It seems that there is a potential involvement of ACE2 and TMPRSS2 expressions in the virus infection of extrapulmonary organs and the manifestation of symptoms related to these organs in patients with COVID-19. Here, we revealed the expressions of ACE2 and TMPRSS2 in extrapulmonary organs, and we also summarized the clinical manifestation and the management of extrapulmonary complications in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110678

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110678