GRP78 targeting: Hitting two birds with a stone.
Life Sci
; 260: 118317, 2020 Nov 01.
Article
in English
| MEDLINE | ID: covidwho-726683
ABSTRACT
BACKGROUND:
Glucose regulating protein 78 (GRP78) is one member of the Heat Shock Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of the Unfolded Protein Response (UPR) process in the lumen of the Endoplasmic Reticulum (ER). SCOPE Under the stress of unfolded proteins, GRP78 binds to the unfolded proteins to prevent misfolding, while under the load of the unfolded protein, it drives the cell to autophagy or apoptosis. Several attempts reported the overexpression of GRP78 on the cell membrane of cancer cells and cells infected with viruses or fungi. MAJORCONCLUSIONS:
Cell-surface GRP78 is used as a cancer cell target in previous studies. Additionally, GRP78 is used as a drug target to stop the progression of cancer cells by different compounds, including peptides, antibodies, and some natural compounds. Additionally, it can be used as a protein target to reduce the infectivity of different viruses, including the pandemic SARS-CoV-2. Besides, GRP78 targeting is used in diagnosis and imaging modalities using radionuclides. GENERALSIGNIFICANCE:
This review summarizes the various attempts that used GRP78 both in therapy (fighting cancer, viral and fungal infections) and diagnosis (imaging).Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Biological Products
/
Coronavirus Infections
/
Molecular Targeted Therapy
/
Betacoronavirus
/
Heat-Shock Proteins
/
Neoplasms
/
Antineoplastic Agents
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Life Sci
Year:
2020
Document Type:
Article
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