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Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19.
Baller, Erica B; Hogan, Charlotte S; Fusunyan, Mark A; Ivkovic, Ana; Luccarelli, James W; Madva, Elizabeth; Nisavic, Mladen; Praschan, Nathan; Quijije, Nadia V; Beach, Scott R; Smith, Felicia A.
  • Baller EB; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA. Electronic address: eballer@mgh.harvard.edu.
  • Hogan CS; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Fusunyan MA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Ivkovic A; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Luccarelli JW; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Madva E; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Nisavic M; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Praschan N; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Quijije NV; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Beach SR; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
  • Smith FA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
Psychosomatics ; 61(6): 585-596, 2020.
Article in English | MEDLINE | ID: covidwho-726823
ABSTRACT

BACKGROUND:

The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the biggest health threats of our generation. A significant portion of patients are presenting with delirium and neuropsychiatric sequelae of the disease. Unique examination findings and responses to treatment have been identified.

OBJECTIVE:

In this article, we seek to provide pharmacologic and treatment recommendations specific to delirium in patients with COVID-19.

METHODS:

We performed a literature search reviewing the neuropsychiatric complications and treatments in prior coronavirus epidemics including Middle Eastern respiratory syndrome and severe acute respiratory syndrome coronaviruses, as well as the emerging literature regarding COVID-19. We also convened a work group of consultation-liaison psychiatrists actively managing patients with COVID-19 in our hospital. Finally, we synthesized these findings to provide preliminary pharmacologic recommendations for treating delirium in these patients.

RESULTS:

Delirium is frequently found in patients who test positive for COVID-19, even in the absence of respiratory symptoms. There appears to be a higher rate of agitation, myoclonus, abulia, and alogia. No data are currently available on the treatment of delirium in patients with COVID-19. Extrapolating from general delirium treatment, Middle Eastern respiratory syndrome/severe acute respiratory syndrome case reports, and our experience, preliminary recommendations for pharmacologic management have been assembled.

CONCLUSIONS:

COVID-19 is associated with neuropsychiatric symptoms. Low-potency neuroleptics and alpha-2 adrenergic agents may be especially useful in this setting. Further research into the pathophysiology of COVID-19 will be key in developing more targeted treatment guidelines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Antipsychotic Agents / Brain Diseases / Coronavirus Infections / Dopamine Agonists / Delirium / Adrenergic alpha-2 Receptor Agonists Type of study: Prognostic study / Qualitative research Topics: Long Covid Limits: Humans Language: English Journal: Psychosomatics Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Antipsychotic Agents / Brain Diseases / Coronavirus Infections / Dopamine Agonists / Delirium / Adrenergic alpha-2 Receptor Agonists Type of study: Prognostic study / Qualitative research Topics: Long Covid Limits: Humans Language: English Journal: Psychosomatics Year: 2020 Document Type: Article