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A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
Bektas, Arsun; Schurman, Shepherd H; Franceschi, Claudio; Ferrucci, Luigi.
  • Bektas A; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224 USA.
  • Schurman SH; Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Research Triangle Park, NC 27709 USA.
  • Franceschi C; Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Ferrucci L; Laboratory of Systems Biology of Healthy Aging and Department of Applied Mathematics, Lobachevsky State University, Nizhny Novgorod, Russia.
Immun Ageing ; 17: 23, 2020.
Article in English | MEDLINE | ID: covidwho-727283
ABSTRACT
A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover from the hyperinflammatory state characterizing COVID-19 and in particular for the hundreds of thousands who are ill enough to need hospitalization and in particular ICU care. Even when the pandemic is finally controlled, will COVID-19 survivors face exaggerated internal inflammatory processes, worsening co-morbidities, and increased susceptibility to age-related diseases? Clues for what may happen in post-COVID-19 patients can be elicited from those who recovered from other conditions that lead to similar hyperinflammatory states such as Severe Acute Respiratory Syndrome (SARS), acute respiratory disease syndrome (ARDS), cytokine storm syndrome, and post-ICU syndrome. The short-and long-term sequalae following recovery from each of these conditions suggests that these syndromes lead to an accelerated state of chronic subclinical systemic inflammation often seen in aging (termed inflammaging) resulting in increased and worsening age-related conditions including frailty even in younger individuals.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Long Covid Language: English Journal: Immun Ageing Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Long Covid Language: English Journal: Immun Ageing Year: 2020 Document Type: Article