Neurological manifestations of COVID-19: available evidences and a new paradigm.
J Neurovirol
; 26(5): 619-630, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-728290
ABSTRACT
The recent pandemic outbreak of coronavirus is pathogenic and a highly transmittable viral infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). In this time of ongoing pandemic, many emerging reports suggested that the SARS-CoV-2 has inimical effects on neurological functions, and even causes serious neurological damage. The neurological symptoms associated with COVID-19 include headache, dizziness, depression, anosmia, encephalitis, stroke, epileptic seizures, and Guillain-Barre syndrome along with many others. The involvement of the CNS may be related with poor prognosis and disease worsening. Here, we review the evidence of nervous system involvement and currently known neurological manifestations in COVID-19 infections caused by SARS-CoV-2. We prioritize the 332 human targets of SARS-CoV-2 according to their association with brain-related disease and identified 73 candidate genes. We prioritize these 73 genes according to their spatio-temporal expression in the different regions of brain and also through evolutionary intolerance analysis. The prioritized genes could be considered potential indicators of COVID-19-associated neurological symptoms and thus act as a possible therapeutic target for the prevention and treatment of CNS manifestations associated with COVID-19 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Viral Proteins
/
Brain
/
Coronavirus Infections
/
Host-Pathogen Interactions
/
Betacoronavirus
/
Nerve Tissue Proteins
Type of study:
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
J Neurovirol
Journal subject:
Neurology
/
Virology
Year:
2020
Document Type:
Article
Affiliation country:
S13365-020-00895-4
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