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Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kinetics.
Liu, Wang-Da; Chang, Sui-Yuan; Lan, Ting-Yuan; Lin, Yen-Chun; Kao, Jui-Hung; Liao, Chun-Hua; Tsai, Ming-Jui; Kuo, Po-Hsien; Huang, Yu-Shan; Wang, Jann-Tay; Sheng, Wang-Huei; Hsieh, Song-Chou; Chiang, Bor-Luen; Chen, Yee-Chun; Chang, Shan-Chwen.
  • Liu WD; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: b95401043@ntu.edu.tw.
  • Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: sychang@ntu.edu.tw.
  • Lan TY; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: d20023579@gmail.com.
  • Lin YC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: b95401009@ntu.edu.tw.
  • Kao JH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: juihungkaotw@gmail.com.
  • Liao CH; Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan. Electronic address: shiva90345@gmail.com.
  • Tsai MJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: fiophoenix@gmail.com.
  • Kuo PH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: kphsien@gmail.com.
  • Huang YS; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: b101091021@gmail.com.
  • Wang JT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: wang.jt1968@gmail.com.
  • Sheng WH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: whsheng@nt
  • Hsieh SC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: hsiehsc@ntu.edu.tw.
  • Chiang BL; Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: gicmbor@ntu.edu.tw.
  • Chen YC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: yeechunchen@gmail.com.
  • Chang SC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: changsc@ntu.edu.tw.
J Formos Med Assoc ; 120(5): 1269-1273, 2021 May.
Article in English | MEDLINE | ID: covidwho-728694
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
Predicate
TREATS
Object
COVID-19
3. hydroxychloroquine ADMINISTERED_TO Patients
Subject
hydroxychloroquine
Predicate
ADMINISTERED_TO
Object
Patients
4. Low Level PROCESS_OF Patients
Subject
Low Level
Predicate
PROCESS_OF
Object
Patients
5. IL17A protei INTERACTS_WITH C0020336
Subject
IL17A protei
Predicate
INTERACTS_WITH
Object
C0020336
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
Predicate
TREATS
Object
COVID-19
8. hydroxychloroquine ADMINISTERED_TO Patients
Subject
hydroxychloroquine
Predicate
ADMINISTERED_TO
Object
Patients
9. Low Level PROCESS_OF Patients
Subject
Low Level
Predicate
PROCESS_OF
Object
Patients
10. IL17A protein, human|IL17A INTERACTS_WITH hydroxychloroquine
Subject
IL17A protein, human|IL17A
Predicate
INTERACTS_WITH
Object
hydroxychloroquine
ABSTRACT
Until now, there are no approved treatment against COVID-19. Hydroxychloroquine (HCQ) was hypothesized to be active against SARS-CoV2 via antiviral and anti-inflammatory effect; however, HCQ for COVID-19 in clinical use remained debating. In this preliminary report, we presented six patients with mild to moderate COVID-19. They were treated with HCQ for 14 days from the day of COVID-19 diagnosis. Serial viral load from respiratory specimens were performed every other day. Cytokine profile was checked before HCQ initiation and on the 14th day of HCQ treatment. All patients receiving HCQ completed 14-day course without complication. Among the six patients, the mean duration from symptom onset to last detectable viral load was 34 ± 12 days, which was similar to those without specific treatment in previous reports. Low level of interferon-gamma was noted in all patients of different stage of infection and three patients had elevation of IL-17 level. Prolonged virus shedding is still observed regardless HCQ. The impact of HCQ on cytokine kinetics remained unclear; however, IL-17 could be an inflammatory marker for disease status monitor and a potential therapeutic target.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydroxychloroquine Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Formos Med Assoc Journal subject: Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydroxychloroquine Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Formos Med Assoc Journal subject: Medicine Year: 2021 Document Type: Article