iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2.
ACS Chem Neurosci
; 11(17): 2489-2491, 2020 09 02.
Article
in English
| MEDLINE | ID: covidwho-728963
ABSTRACT
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) Cell Res. DOI 10.1038/s41422-020-0390-x).
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Brain
/
Coronavirus Infections
/
Induced Pluripotent Stem Cells
/
Betacoronavirus
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
ACS Chem Neurosci
Year:
2020
Document Type:
Article
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