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Rapid establishment of a COVID-19 convalescent plasma program in a regional health care delivery network.
Blackall, Douglas; Wulff, Shephali; Roettger, Timothy; Jacobs, Lauren; Lacasse, Alexandre; Patri, Manokiran; Zinser, Phillip; Pherez, Francisco; Jamkhana, Zafar; Frey, Sharon E; Smith, Linda; Goel, Ruchika; Katz, Louis.
  • Blackall D; Department of Pathology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
  • Wulff S; SSM Health Saint Joseph Hospital, Saint Charles, Missouri, USA.
  • Roettger T; SSM-STL Pharmacy, Saint Louis, Missouri, USA.
  • Jacobs L; SSM-STL Pharmacy, Saint Louis, Missouri, USA.
  • Lacasse A; SSM Health Saint Mary's Hospital, Saint Louis, Missouri, USA.
  • Patri M; SSM Health DePaul Hospital, Bridgeton, Missouri, USA.
  • Zinser P; SSM Health DePaul Hospital, Bridgeton, Missouri, USA.
  • Pherez F; SSM Health Saint Clare Hospital, Fenton, Missouri, USA.
  • Jamkhana Z; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
  • Frey SE; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
  • Smith L; SSM-STL Laboratory, Saint Louis, Missouri, USA.
  • Goel R; Mississippi Valley Regional Blood Center, Springfield, Illinois, USA.
  • Katz L; Mississippi Valley Regional Blood Center, Springfield, Illinois, USA.
Transfusion ; 60(10): 2203-2209, 2020 10.
Article in English | MEDLINE | ID: covidwho-729352
ABSTRACT

BACKGROUND:

COVID-19 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due to SARS-CoV-2. We endeavored to quickly establish a sustainable CCP transfusion program for a regional network of health care facilities. STUDY DESIGN AND

METHODS:

A regional collaborative group was activated to address the issues necessary to implementing a CCP transfusion program and making the program sustainable. A wide range of health care providers including physicians (critical care, infectious disease, transfusion medicine), nurses, pharmacists, laboratorians, and information technology (IT) specialists were required to make the program a success.

RESULTS:

The CCP implementation team initially consisted of four members but quickly grew to a group of nearly 20 participants based on different issues related to program implementation. Overall, six major implementation "themes" were addressed (a) registration of individual hospitals and principal investigators with a national investigational new drug research protocol; (b) collaboration with a regional blood donor center; (c) targeted recruitment of convalesced donors; (d) IT issues related to all aspects of CCP ordering, distribution, and transfusion; (e) prioritization of patients to receive CCP; and (f) evaluation of CCP products including antibody characteristics and patient response to therapy.

CONCLUSION:

Within 4 weeks of initiation, CCP was successfully transfused at multiple hospitals in our regional health care delivery system. A program infrastructure was established that will make this program sustainable into the future. This approach has broader implications for the success of multi-institutional programs requiring rapid implementation.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Transfusion Year: 2020 Document Type: Article Affiliation country: Trf.16026

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Transfusion Year: 2020 Document Type: Article Affiliation country: Trf.16026