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Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019.
Zayed, Mohammed; Iohara, Koichiro.
  • Zayed M; Department of Stem Cell Biology and Regenerative Medicine, 221156National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan.
  • Iohara K; Department of Surgery, College of Veterinary Medicine, South Valley University, Qena, Egypt.
Cell Transplant ; 29: 963689720952089, 2020.
Article in English | MEDLINE | ID: covidwho-729480
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, originating from Wuhan, China, is known to cause severe acute respiratory symptoms. The occurrence of a cytokine storm in the lungs is a critical step in the disease pathogenesis, as it causes pathological lesions, pulmonary edema, and acute respiratory distress syndrome, potentially resulting in death. Currently, there is no effective treatment that targets the cytokine storm and helps regenerate the damaged tissue. Mesenchymal stem cells (MSCs) are known to act as anti-inflammatory/immunomodulatory candidates and activate endogenous regeneration. As a result, MSC therapy is a potential treatment approach for COVID-19. Intravenous injection of clinical-grade MSCs into COVID-19 patients can induce an immunomodulatory response along with improved lung function. Dental pulp stem cells (DPSCs) are considered a potential source of MSCs for immunomodulation, tissue regeneration, and clinical application. Although some current clinical trials have treated COVID-19 patients with DPSCs, this therapy has not been approved. Here, we review the potential use of DPSCs and their significance in the development of a therapy for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Dental Pulp / Mesenchymal Stem Cell Transplantation / Immunomodulation / Mesenchymal Stem Cells Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cell Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: 0963689720952089

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Dental Pulp / Mesenchymal Stem Cell Transplantation / Immunomodulation / Mesenchymal Stem Cells Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cell Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: 0963689720952089