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Is periodontal disease a risk factor for developing severe Covid-19 infection? The potential role of Galectin-3.
Kara, Cankat; Çelen, Kübra; Dede, Figen Öngöz; Gökmenoglu, Ceren; Kara, Nihal Beldüz.
  • Kara C; Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu 52100, Turkey.
  • Çelen K; Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu 52100, Turkey.
  • Dede FÖ; Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu 52100, Turkey.
  • Gökmenoglu C; Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu 52100, Turkey.
  • Kara NB; Department of Pedodontics, Faculty of Dentistry, Ordu University, Ordu 52100, Turkey.
Exp Biol Med (Maywood) ; 245(16): 1425-1427, 2020 10.
Article in English | MEDLINE | ID: covidwho-729490
ABSTRACT
IMPACT STATEMENT There could be a close relationship between periodontal diseases (PDs) severity and Covid-19 infections. This relationship could be caused by Galectin-3-mediated increased immune response and increased viral attachment. Keeping PDs under control and maintaining rigorous oral hygiene during this troubled Covid-19 pandemic period is very important.Patients with older age and pre-existing conditions like cardiovascular disease, hypertension, diabetes, and obesity are in the higher risk group for developing severe Covid-19 infections. The inflammatory pathways that are involved in these conditions are the same pathways that we see in periodontal diseases (PDs). This raises a significant question Is PD a pre-existing condition that can increase the risk of developing severe Covid-19 infection? Several studies have shown that Galectins play a key role in the homeostasis of immune cells, and recently, a relationship was found between Covid-19 and Galectin-3 (Gal-3).It has been determined that an important area in the spike protein of Coronavirus-19 is almost exactly the same as the morphology of Gal-3, and these spike proteins are critical for the entry of the virus into host cells. We suspect that there is enough evidence to support a close relationship between PDs severity and Covid-19 infections. There is accumulating evidence to suggest a relationship between the severity of PD and the risk of infection with Covid-19, which requires further investigation. This relationship could be caused by Gal-3-mediated increased immune response and increased viral attachment. In this context, we want to emphasize the importance of keeping PD under control by maintaining rigorous oral hygiene during this troubled Covid-19 pandemic period. We would also like to point out the possibility that having PD may be a pre-disposition toward developing a severe Covid-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontal Diseases / Pneumonia, Viral / Coronavirus Infections / Galectin 3 / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2020 Document Type: Article Affiliation country: 1535370220953771

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontal Diseases / Pneumonia, Viral / Coronavirus Infections / Galectin 3 / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2020 Document Type: Article Affiliation country: 1535370220953771