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Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2.
Patil, Ashwini M; Göthert, Joachim R; Khairnar, Vishal.
  • Patil AM; Department of Hematology, West German Cancer Center (WTZ), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
  • Göthert JR; Department of Hematology, West German Cancer Center (WTZ), University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
  • Khairnar V; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, khairnarvs111@gmail.com.
Cell Physiol Biochem ; 54(4): 767-790, 2020 Aug 25.
Article in English | MEDLINE | ID: covidwho-729851
ABSTRACT
The pandemic of the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 at the end of 2019 marked the third outbreak of a highly pathogenic coronavirus affecting the human population in the past twenty years. Cross-species zoonotic transmission of SARS-CoV-2 has caused severe pathogenicity and led to more than 655,000 fatalities worldwide until July 28, 2020. Outbursts of this virus underlined the importance of controlling infectious pathogens across international frontiers. Unfortunately, there is currently no clinically approved antiviral drug or vaccine against SARS-CoV-2, although several broad-spectrum antiviral drugs targeting multiple RNA viruses have shown a positive response and improved recovery in patients. In this review, we compile our current knowledge of the emergence, transmission, and pathogenesis of SARS-CoV-2 and explore several features of SARS-CoV-2. We emphasize the current therapeutic approaches used to treat infected patients. We also highlight the results of in vitro and in vivo data from several studies, which have broadened our knowledge of potential drug candidates for the successful treatment of patients infected with and discuss possible virus and host-based treatment options against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2020 Document Type: Article Affiliation country: 000000254

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2020 Document Type: Article Affiliation country: 000000254