Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage.
Acta Neuropathol Commun
; 8(1): 147, 2020 08 26.
Article
in English
| MEDLINE | ID: covidwho-730088
ABSTRACT
We document the neuropathologic findings of a 73-year old man who died from acute cerebellar hemorrhage in the context of relatively mild SARS-CoV2 infection. The patient developed sudden onset of headache, nausea, and vomiting, immediately followed by loss of consciousness on the day of admission. Emergency medical services found him severely hypoxemic at home, and the patient suffered a cardiac arrest during transport to the emergency department. The emergency team achieved return of spontaneous circulation after over 17 min of resuscitation. A chest radiograph revealed hazy bilateral opacities; and real-time-PCR for SARS-CoV-2 on the nasopharyngeal swab was positive. Computed tomography of the head showed a large right cerebellar hemorrhage, with tonsillar herniation and intraventricular hemorrhage. One day after presentation, he was transitioned to comfort care and died shortly after palliative extubation. Autopsy performed 3 h after death showed cerebellar hemorrhage and acute infarcts in the dorsal pons and medulla. Remarkably, there were microglial nodules and neuronophagia bilaterally in the inferior olives and multifocally in the cerebellar dentate nuclei. This constellation of findings has not been reported thus far in the context of SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phagocytosis
/
Pneumonia, Viral
/
Cerebellar Diseases
/
Microglia
/
Coronavirus Infections
/
Brain Stem Infarctions
/
Intracranial Hemorrhages
/
Neurons
Type of study:
Case report
/
Diagnostic study
Topics:
Long Covid
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Acta Neuropathol Commun
Year:
2020
Document Type:
Article
Affiliation country:
S40478-020-01024-2
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