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Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States.
Molnar, Miklos Z; Bhalla, Anshul; Azhar, Ambreen; Tsujita, Makoto; Talwar, Manish; Balaraman, Vasanthi; Sodhi, Amik; Kadaria, Dipen; Eason, James D; Hayek, Salim S; Coca, Steven G; Shaefi, Shahzad; Neyra, Javier A; Gupta, Shruti; Leaf, David E; Kovesdy, Csaba P.
  • Molnar MZ; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Bhalla A; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Azhar A; Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Tsujita M; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Talwar M; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Balaraman V; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Sodhi A; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Kadaria D; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Eason JD; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Hayek SS; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Coca SG; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Shaefi S; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
  • Neyra JA; Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Gupta S; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Leaf DE; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Kovesdy CP; James D. Eason Transplant Institute, Methodist University Hospital, Memphis, Tennessee, USA.
Am J Transplant ; 20(11): 3061-3071, 2020 11.
Article in English | MEDLINE | ID: covidwho-730135
ABSTRACT
National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. From 4153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non-SOT patients. We used a binomial generalized linear model (log-binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non-SOT patients (40% and 43%, respectively; relative risk [RR] 0.92; 95% confidence interval [CI] 0.70-1.22). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. 27%; RR [95% CI] 1.34 [0.97-1.85]). Death and organ support requirement were similar between SOT and non-SOT critically ill patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Critical Illness / Pandemics / SARS-CoV-2 / COVID-19 / Hospitalization / Intensive Care Units Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16280

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Critical Illness / Pandemics / SARS-CoV-2 / COVID-19 / Hospitalization / Intensive Care Units Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16280