Safety and Efficacy of Hydroxychloroquine in COVID-19: A Systematic Review and Meta-Analysis.
J Clin Med Res
; 12(8): 483-491, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-732647
ABSTRACT
BACKGROUND:
During the initial phases of the coronavirus disease 2019 (COVID-19) epidemic, there was an unfounded fervor surrounding the use of hydroxychloroquine (HCQ); however, recently, the Centers for Disease Control and Prevention (CDC) has recommended against routine use of HCQ outside of study protocols citing possible adverse outcomes.METHODS:
Multiple databases were searched to identify articles on COVID-19. An unadjusted odds ratio (OR) was used to calculate the safety and efficacy of HCQ on a random effect model.RESULTS:
Twelve studies comprising 3,912 patients (HCQ 2,512 and control 1400) were included. The odds of all-cause mortality (OR 2.23, 95% confidence interval (CI) 1.58 - 3.13, P value < 0.00001) were significantly higher in patients on HCQ compared to patients on control agent. The response to therapy assessed by negative repeat polymerase chain reaction (PCR) (OR 1.83, 95% CI 0.50 - 6.75, P = 0.36), radiological resolution (OR 1.98, 95% CI 0.47 - 8.36, P value = 0.36) and the need for invasive mechanical ventilation (IMV) (OR 1.21, 95% CI 0.34 - 4.33, P value = 0.76) were identical between the two groups. Overall, four times higher odds of net adverse events (NAEs) were observed in the HCQ group (OR 4.59, 95% CI 1.73 - 12.20, P value = 0.02). The measures for individual safety endpoints were also numerically lower in the control arm; however, none of these values reached the level of statistical significance.CONCLUSIONS:
HCQ might offer no benefits in terms of decreasing the viral load and radiological improvement in patients with COVID-19. HCQ appears to be associated with higher odds of all-cause mortality and NAEs.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
J Clin Med Res
Year:
2020
Document Type:
Article
Affiliation country:
Jocmr4233
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