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Combination Therapy Using Inhalable GapmeR and Recombinant ACE2 for COVID-19.
Verma, Navin Kumar; Fazil, Mobashar Hussain Urf Turabe; Duggan, Shane P; Kelleher, Dermot.
  • Verma NK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Fazil MHUT; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Duggan SP; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Kelleher D; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Front Mol Biosci ; 7: 197, 2020.
Article in English | MEDLINE | ID: covidwho-732872
Semantic information from SemMedBD (by NLM)
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ABSTRACT
Here we report our perspective on applying GapmeR technology in combination with recombinant angiotensin-converting enzyme 2 (ACE2) in the treatment of COVID-19 patients. GapmeR is a cell-permeating antisense single-stranded DNA molecule that can be designed to specifically target intracellular severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Once internalized into host cells, such as lung alveolar cells, GapmeR molecules can bind to the viral RNA. This RNA/DNA hybrid will then be degraded by the RNase H enzyme abundantly present in the host cells. GapmeRs can be delivered to COVID-19 patients through inhalation or via nebulization. SARS-CoV-2-targeted GapmeR can also be given to frontline healthcare workers as a prophylactic protection. The recombinant ACE2 protein, the efficacy of which is being evaluated in clinical trials, will bind to the spike (S) glycoprotein of extracellular SARS-CoV-2 and potentially block viral infectivity. We propose that combining inhalable SARS-CoV-2-targeted GapmeRs with recombinant ACE2 could provide a viable and rapidly implementable more effective therapeutic approach for eradicating SARS-CoV-2 and save millions of lives.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Front Mol Biosci Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Journal: Front Mol Biosci Year: 2020
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